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'''KiSS1-izvedeni peptidni receptor''' (takođe poznat kao KISS1R, ''GPR54'' ili ''Kispeptinski receptor'') je [[G protein spregnuti receptori|G protein-spregnuti receptor]]<ref name="pmid10100623">{{cite journal | author = Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF | title = Discovery of a receptor related to the galanin receptors | journal = FEBS Lett. | volume = 446 | issue = 1 | pages = 103–7 | year = 1999 | pmid = 10100623 | doi = 10.1016/S0014-5793(99)00009-5 }}</ref> koji vezuje peptidni hormon ''[[kispeptin]]'' (''metastin'').<ref name="pmid11385580">{{cite journal | author = Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M | title = Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor | journal = Nature | volume = 411 | issue = 6837 | pages = 613–7 | year = 2001 | pmid = 11385580 | doi = 10.1038/35079135 }}</ref><ref name="pmid11387329">{{cite journal | author = Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC | title = AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1 | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28969–75 | year = 2001 | pmid = 11387329 | doi = 10.1074/jbc.M102743200 }}</ref><ref name="pmid11457843">{{cite journal | author = Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M | title = The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 | journal = J. Biol. Chem. | volume = 276 | issue = 37 | pages = 34631–6 | year = 2001 | pmid = 11457843 | doi = 10.1074/jbc.M104847200 }}</ref> Kispeptin je kodiran genom [[supresor metastaze|supresora metastaze]] [[Kispeptin|KISS1]], koji je izražen u raznim [[Endokrini sistem|endokrinim]] i [[gonada|gonadnim]] tkivima.<ref name="pmid18948153">{{cite journal |author=Richard N, Corvaisier S, Camacho E, Kottler ML |title=KiSS-1 and GPR54 at the pituitary level: overview and recent insights |journal=Peptides |volume=30 |issue=1 |pages=123–9 |year=2009 |month=January |pmid=18948153 |doi=10.1016/j.peptides.2008.09.015 |url=}}</ref> Aktivacija kispeptinskog receptora je vezana sa kaskadom [[fosfolipaza C|fosfolipaze C]] i [[inozitol trifosfat|inozitol trisfosfata]] u ćelija.<ref name="pmid18483150">{{cite journal |author=Liu X, Lee K, Herbison AE |title=Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels |journal=Endocrinology |volume=149 |issue=9 |pages=4605–14 |year=2008 |month=September |pmid=18483150 |doi=10.1210/en.2008-0321 |url=}}</ref>

== Funkcija ==
Kispeptin učestvuje u regulaciji endokrinih funkcija i početka [[pubertet]]a. Aktivacija kispeptinskog receptora inicira otpuštanje [[gonadotropin-oslobađajući hormon|gonadotropin-oslobađajućeg hormona]] (GnRH).<ref name="pmid15684075">{{cite journal |author=Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM |title=Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=102 |issue=6 |pages=2129–34 |year=2005 |month=February |pmid=15684075 |pmc=548549 |doi=10.1073/pnas.0409822102 |url=}}</ref><ref name="pmid16282350">{{cite journal |author=Plant TM, Ramaswamy S, Dipietro MJ |title=Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges |journal=Endocrinology |volume=147 |issue=2 |pages=1007–13 |year=2006 |month=February |pmid=16282350 |doi=10.1210/en.2005-1261 |url=}}</ref> Otpuštanje samog kispeptina inhibira [[estradiol]], a podstiče GnRH.<ref name="pmid18208554">{{cite journal |author=Richard N, Galmiche G, Corvaisier S, Caraty A, Kottler ML |title=KiSS-1 and GPR54 genes are co-expressed in rat gonadotrophs and differentially regulated in vivo by oestradiol and gonadotrophin-releasing hormone |journal=Journal of Neuroendocrinology |volume=20 |issue=3 |pages=381–93 |year=2008 |month=March |pmid=18208554 |doi=10.1111/j.1365-2826.2008.01653.x |url=}}</ref> Snižavanje nivoa kispeptina sa godinama je jedan od mogućih razloga za opadanje nivoa drugih endokrinih hormona, kao što je [[luteinizirajući hormon]].<ref name="pmid19423763">{{cite journal |author=Neal-Perry G, Lebesgue D, Lederman M, Shu J, Zeevalk GD, Etgen AM |title=The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged rats |journal=Endocrinology |volume= 150|issue= 8|pages= 3699–708|year=2009 |month=May |pmid=19423763 |doi=10.1210/en.2008-1667 |url= |pmc=2717872}}</ref>

== Ligandi ==
Svi poznati ligandi su peptidi. Selektivni agonisti i antagonisti su otkriveni [[2009]].

=== Agonisti ===
* [[Kispeptin]]
* Kispeptin-10 (112-121 C-terminalni fragment)<ref name="pmid18940206">{{cite journal |author=Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A |title=Comparison of the effects of peripherally administered kisspeptins |journal=Regulatory Peptides |volume=152 |issue=1-3 |pages=95–100 |year=2009 |month=January |pmid=18940206 |doi=10.1016/j.regpep.2008.10.001 |url=}}</ref>

=== Antagonisti ===
* Kispeptin-10 analozi modifikovani amino supstitucijama.<ref name="pmid19321788">{{cite journal |author=Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP |title=Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation |journal=The Journal of Neuroscience : the Official Journal of the Society for Neuroscience |volume=29 |issue=12 |pages=3920–9 |year=2009 |month=March |pmid=19321788 |pmc=3035813 |doi=10.1523/JNEUROSCI.5740-08.2009 |url=}}</ref>

== Literatura ==
{{reflist|2}}

== Dodatna literatura ==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Colledge WH |title=GPR54 and puberty. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 9 |pages= 448–53 |year= 2005 |pmid= 15519892 |doi= 10.1016/j.tem.2004.09.008 }}
*{{cite journal  | author=Kaiser UB, Kuohung W |title=KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. |journal=Endocrine |volume=26 |issue= 3 |pages= 277–84 |year= 2006 |pmid= 16034182 |doi=10.1385/ENDO:26:3:277  }}
*{{cite journal  | author=Seminara SB |title=Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion. |journal=Frontiers in neuroendocrinology |volume=26 |issue= 3-4 |pages= 131–8 |year= 2006 |pmid= 16309735 |doi= 10.1016/j.yfrne.2005.10.001 }}
*{{cite journal  | author=Tena-Sempere M |title=GPR54 and kisspeptin in reproduction. |journal=Hum. Reprod. Update |volume=12 |issue= 5 |pages= 631–9 |year= 2006 |pmid= 16731583 |doi= 10.1093/humupd/dml023 }}
*{{cite journal  | author=Cerrato F, Seminara SB |title=Human genetics of GPR54. |journal=Reviews in endocrine & metabolic disorders |volume=8 |issue= 1 |pages= 47–55 |year= 2007 |pmid= 17334928 |doi= 10.1007/s11154-007-9027-3 }}
*{{cite journal  | author=Lee DK, Nguyen T, O'Neill GP, ''et al.'' |title=Discovery of a receptor related to the galanin receptors. |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 103–7 |year= 1999 |pmid= 10100623 |doi=10.1016/S0014-5793(99)00009-5  }}
*{{cite journal  | author=Ohtaki T, Shintani Y, Honda S, ''et al.'' |title=Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. |journal=Nature |volume=411 |issue= 6837 |pages= 613–7 |year= 2001 |pmid= 11385580 |doi= 10.1038/35079135 }}
*{{cite journal  | author=Muir AI, Chamberlain L, Elshourbagy NA, ''et al.'' |title=AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28969–75 |year= 2001 |pmid= 11387329 |doi= 10.1074/jbc.M102743200 }}
*{{cite journal  | author=Clements MK, McDonald TP, Wang R, ''et al.'' |title=FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 5 |pages= 1189–93 |year= 2001 |pmid= 11414709 |doi= 10.1006/bbrc.2001.5098 }}
*{{cite journal  | author=Kotani M, Detheux M, Vandenbogaerde A, ''et al.'' |title=The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34631–6 |year= 2001 |pmid= 11457843 |doi= 10.1074/jbc.M104847200 }}
*{{cite journal  | author=Hori A, Honda S, Asada M, ''et al.'' |title=Metastin suppresses the motility and growth of CHO cells transfected with its receptor. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 958–63 |year= 2001 |pmid= 11527393 |doi= 10.1006/bbrc.2001.5470 }}
*{{cite journal  | author=Ringel MD, Hardy E, Bernet VJ, ''et al.'' |title=Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 5 |pages= 2399 |year= 2002 |pmid= 11994395 |doi=10.1210/jc.87.5.2399  }}
*{{cite journal  | author=Janneau JL, Maldonado-Estrada J, Tachdjian G, ''et al.'' |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=10.1210/jc.2002-021093  }}
*{{cite journal  | author=Bo-Abbas Y, Acierno JS, Shagoury JK, ''et al.'' |title=Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2730–7 |year= 2003 |pmid= 12788881 |doi=10.1210/jc.2002-021948  }}
*{{cite journal  | author=Ikeguchi M, Hirooka Y, Kaibara N |title=Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. |journal=J. Cancer Res. Clin. Oncol. |volume=129 |issue= 9 |pages= 531–5 |year= 2003 |pmid= 12898236 |doi= 10.1007/s00432-003-0469-z }}
*{{cite journal  | author=de Roux N, Genin E, Carel JC, ''et al.'' |title=Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10972–6 |year= 2003 |pmid= 12944565 |doi= 10.1073/pnas.1834399100  | pmc=196911 }}
*{{cite journal  | author=Seminara SB, Messager S, Chatzidaki EE, ''et al.'' |title=The GPR54 gene as a regulator of puberty. |journal=N. Engl. J. Med. |volume=349 |issue= 17 |pages= 1614–27 |year= 2003 |pmid= 14573733 |doi= 10.1056/NEJMoa035322 }}
*{{cite journal  | author=Ikeguchi M, Yamaguchi K, Kaibara N |title=Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. |journal=Clin. Cancer Res. |volume=10 |issue= 4 |pages= 1379–83 |year= 2004 |pmid= 14977840 |doi=10.1158/1078-0432.CCR-1519-02  }}
*{{cite journal  | author=Bilban M, Ghaffari-Tabrizi N, Hintermann E, ''et al.'' |title=Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. |journal=J. Cell. Sci. |volume=117 |issue= Pt 8 |pages= 1319–28 |year= 2004 |pmid= 15020672 |doi= 10.1242/jcs.00971 }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
}}
{{refend}}

== Spoljašnje veze ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1337 | title = KiSS1-Derived Peptide Receptors | accessdate =  | author =  | authorlink =  | coauthors =  | date =  | format =  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages =  | language =  | archiveurl = https://web.archive.org/web/20160206094855/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1337 | archivedate = 2016-02-06 | quote =  | dead-url = yes }}
* {{MeshName|KISS1R+protein,+human}}
{{-}}
{{G protein spregnuti receptori-lat}}
{{Neuropeptidni receptori-lat}}
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[[Kategorija:G protein spregnuti receptori]]

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