The tumour microenvironment is of critical importance in cancer development and progression
and includes the surrounding stromal and immune cells, extracellular matrix, and the …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Background and Objectives Optimal surgical management for gastric cancer remains
controversial. We aimed to perform a network meta-analysis (NMA) of randomized clinical trials (…

Background: The FLOT protocol and the CROSS trimodality regimen represent current
standards in the management of locally advanced esophageal adenocarcinoma. In the absence …

Purpose Anastomotic leak (AL) following colorectal cancer resection is associated with
considerable morbidity and mortality with an impact on recurrence rates and survival. The impact …

Surgical site infections are a common source of post-operative morbidity and contribute
significantly to healthcare costs. Patients undergoing emergency laparotomy and/or bowel …

Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-oesophageal
reflux disease, obesity and tobacco use. Knowledge of the microenvironment of …

Study design: An observational cohort study on consecutive patients at 3 tertiary centers
undergoing FLOT and TTE. Toxicity, operative complications (per ECCG definitions), tumor …

Background Chyle leakage is an uncommon but potentially life-threatening complication
following esophageal resections. The optimal management strategy is not clear, with a limited …

Objective: The aim of this study was to propose and test a novel adverse pathology
classification in AEG. Background: Recent scientific advances show genomic and molecular …