SM-Youtube

Year	Number of Results
2002	2
2003	6
2004	8
2005	7
2006	11
2007	9
2008	18
2009	25
2010	24
2011	34
2012	23
2013	34
2014	35
2015	40
2016	44
2017	39
2018	39
2019	32
2020	41
2021	30
2022	17
2023	17
2024	17
2025	4

1

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Sarbassov DD, et al. Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148. Science. 2005. PMID: 15718470

2

Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

Cui Z, Napolitano G, de Araujo MEG, Esposito A, Monfregola J, Huber LA, Ballabio A, Hurley JH. Cui Z, et al. Nature. 2023 Feb;614(7948):572-579. doi: 10.1038/s41586-022-05652-7. Epub 2023 Jan 25. Nature. 2023. PMID: 36697823 Free PMC article.

3

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.

4

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.

He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ. He A, et al. Mol Cell. 2020 Jul 2;79(1):30-42.e4. doi: 10.1016/j.molcel.2020.05.007. Epub 2020 May 29. Mol Cell. 2020. PMID: 32473093 Free PMC article.

5

O-GlcNAcylation of Raptor transduces glucose signals to mTORC1.

Xu C, Pan X, Wang D, Guan Y, Yang W, Chen X, Liu Y. Xu C, et al. Mol Cell. 2023 Aug 17;83(16):3027-3040.e11. doi: 10.1016/j.molcel.2023.07.011. Epub 2023 Aug 3. Mol Cell. 2023. PMID: 37541260 Free article.

6

Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent.

Yan XL, Pan YH, Fan RZ, Song QQ, Li S, Huang JL, Li W, Huang D, Yuan FY, Tang GH, Rao Y, Huang ZS, Yin S. Yan XL, et al. J Med Chem. 2023 Apr 27;66(8):5839-5858. doi: 10.1021/acs.jmedchem.3c00067. Epub 2023 Apr 4. J Med Chem. 2023. PMID: 37014798

7

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP. Yang H, et al. Nature. 2017 Dec 21;552(7685):368-373. doi: 10.1038/nature25023. Epub 2017 Dec 13. Nature. 2017. PMID: 29236692 Free PMC article.

8

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Gwinn DM, et al. Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003. Mol Cell. 2008. PMID: 18439900 Free PMC article.

9

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925 Free article.

10

Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice.

Dai Q, Xie F, Han Y, Ma X, Zhou S, Jiang L, Zou W, Wang J. Dai Q, et al. J Biol Chem. 2017 Jan 6;292(1):196-204. doi: 10.1074/jbc.M116.764761. Epub 2016 Nov 22. J Biol Chem. 2017. PMID: 27879318 Free PMC article.

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