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Meta-Analysis
. 2024 Jan 20;24(1):117.
doi: 10.1186/s12903-024-03850-5.

Vitamin intake and periodontal disease: a meta-analysis of observational studies

Nannan Mi  1 , Miaomiao Zhang  1 , Zheng Ying  1 , Xiaoping Lin  1 , Ying Jin  2
Affiliations
Meta-Analysis

Vitamin intake and periodontal disease: a meta-analysis of observational studies

Nannan Mi et al. BMC Oral Health. .

Abstract

Objective: A meta-analysis was performed to assess the epidemiological correlation between dietary intake of various types of vitamin intake and the risk of periodontal disease.

Methods: A comprehensive computerized search was conducted in eight databases, namely PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine Disc, CNKI, VIP, and WanFang Database, and a random effect model was applied to combine pooled odds ratio (ORs) with corresponding 95% confidence intervals (CIs) of the included studies, and the sensitivity analysis was performed to explore the impact of a single study on the comprehensive results.

Results: We finally included 45 effect groups from 23 observational studies, with a total number of study participants of 74,488. The results showed that higher levels of vitamin A (OR: 0.788, 95% CI: 0.640-0.971), vitamin B complex (OR: 0.884, 95% CI: 0.824-0.948), vitamin C (OR: 0.875, 95% CI: 0.775-0.988), vitamin D (OR: 0.964, 95% CI: 0.948-0.981), and vitamin E (OR: 0.868, 95% CI: 0.776-0.971) intake all were negatively correlated with periodontal disease. After removing each study, leave-one-out sensitivity analysis indicated no significant change in the overall results of any of the five meta-analyses.

Conclusions: The results from this meta-analysis demonstrated a negative association between high-dose vitamin A, vitamin B complex, vitamin C, vitamin D, and vitamin E consumption and the likelihood of developing periodontal disease, revealing the significant role of vitamins in preventing periodontal disease.

Keywords: Folate; Meta-analysis; Periodontal disease; Vitamin.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of literature search
Fig. 2
Fig. 2
a Forest plot of the relationship between vitamin A consumption and the prevalence of periodontal disease. b Sensitivity analysis of the association between vitamin B complex intake and periodontal disease
Fig. 3
Fig. 3
a Forest plot of the relationship between vitamin B complex consumption and the prevalence of periodontal disease. b Sensitivity analysis of the association between vitamin B complex intake and periodontal disease
Fig. 4
Fig. 4
a Forest plot of the relationship between vitamin C consumption and the prevalence of periodontal disease. b Sensitivity analysis of the association between vitamin C intake and periodontal disease
Fig. 5
Fig. 5
a Forest plot of the relationship between vitamin D consumption and the prevalence of periodontal disease. b Sensitivity analysis of the association between vitamin D intake and periodontal disease
Fig. 6
Fig. 6
a Forest plot of the relationship between vitamin E consumption and the prevalence of periodontal disease. b Sensitivity analysis of the association between vitamin E intake and periodontal disease
Fig. 7
Fig. 7
Filled funnel plot with pseudo 95% confidence limits about the analysis of vitamin A and periodontal disease
See this image and copyright information in PMC

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