Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep;60(9):5292-5308.
doi: 10.1007/s12035-023-03411-x. Epub 2023 Jun 7.

The NF-κB Pathway: a Focus on Inflammatory Responses in Spinal Cord Injury

Yi Ding  1   2 , Qin Chen  3   4
Affiliations
Review

The NF-κB Pathway: a Focus on Inflammatory Responses in Spinal Cord Injury

Yi Ding et al. Mol Neurobiol. 2023 Sep.

Abstract

Spinal cord injury (SCI) is a type of central nervous system trauma that can lead to severe nerve injury. Inflammatory reaction after injury is an important pathological process leading to secondary injury. Long-term stimulation of inflammation can further deteriorate the microenvironment of the injured site, leading to the deterioration of neural function. Understanding the signaling pathways that regulate responses after SCI, especially inflammatory responses, is critical for the development of new therapeutic targets and approaches. Nuclear transfer factor-κB (NF-κB) has long been recognized as a key factor in regulating inflammatory responses. The NF-κB pathway is closely related to the pathological process of SCI. Inhibition of this pathway can improve the inflammatory microenvironment and promote the recovery of neural function after SCI. Therefore, the NF-κB pathway may be a potential therapeutic target for SCI. This article reviews the mechanism of inflammatory response after SCI and the characteristics of NF-κB pathway, emphasizing the effect of inhibiting NF-κB on the inflammatory response of SCI to provide a theoretical basis for the biological treatment of SCI.

Keywords: Apoptosis; Inflammation; Nuclear transfer factor-κB (NF-κB); Spinal cord injury (SCI); Targeted therapy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cofano F, Boido M, Monticelli M et al (2019) Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy. Int J Mol Sci 20(11):2698 - PubMed - PMC - DOI
    1. Wang H, Liu X, Zhao Y et al (2016) Incidence and pattern of traumatic spinal fractures and associated spinal cord injury resulting from motor vehicle collisions in China over 11 years: an observational study. Medicine 95(43):e5220 - PubMed - PMC - DOI
    1. Chen J, Chen Z, Zhang K et al (2021) Epidemiological features of traumatic spinal cord injury in Guangdong Province, China. J Spinal Cord Med 44(2):276–281 - PubMed - DOI
    1. O'shea TM, Burda JE, Sofroniew MV (2017) Cell biology of spinal cord injury and repair. J Clin Invest 127(9):3259–3270 - PubMed - PMC - DOI
    1. Alonso-Calviño E, Martínez-Camero I, Fernández-López E et al (2016) Increased responses in the somatosensory thalamus immediately after spinal cord injury. Neurobiol Dis 87:39–49 - PubMed - DOI

LinkOut - more resources