Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 4;22(1):128-137.e9.
doi: 10.1016/j.stem.2017.11.005. Epub 2017 Dec 21.

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

Hideo Jinnou  1 , Masato Sawada  2 , Koya Kawase  1 , Naoko Kaneko  2 , Vicente Herranz-Pérez  3 , Takuya Miyamoto  2 , Takumi Kawaue  4 , Takaki Miyata  4 , Yasuhiko Tabata  5 , Toshihiro Akaike  6 , José Manuel García-Verdugo  7 , Itsuki Ajioka  8 , Shinji Saitoh  9 , Kazunobu Sawamoto  10
Affiliations
Free article

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

Hideo Jinnou et al. Cell Stem Cell. .
Free article

Abstract

Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries.

Keywords: N-cadherin; gait behavior; neonatal brain injury; neuronal migration; neuronal regeneration; postnatal neurogenesis; radial glial cell; ventricular-subventricular zone.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types