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. 2015;49(1):70-7.
doi: 10.1159/000362825. Epub 2014 Dec 18.

Early childhood caries is associated with genetic variants in enamel formation and immune response genes

Zerrin Abbasoğlu  1 , İlknur Tanboğa, Erika Calvano Küchler, Kathleen Deeley, Megan Weber, Cigdem Kaspar, May Korachi, Alexandre R Vieira
Affiliations

Early childhood caries is associated with genetic variants in enamel formation and immune response genes

Zerrin Abbasoğlu et al. Caries Res. 2015.

Abstract

Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease.

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References

    1. American Academy on Pediatric Dentistry. Policy on early childhood caries (ECC): Classifications, consequences, and preventive strategies. Pediatr Dent. 2008;30:40–43. - PubMed
    1. Azevedo LF, Pecharki GD, Brancher JA, Cordeiro CA, Jr, Medeitors KG, Antunes AA, Arruda ES, Werneck RI, Azevedo LR, Mazur RF, Moysés ST, Faucz FR, Trevilatto PC. Analyis of the association between lactotransferrin (LTF) gene polymorphism and dental caries. J Appl Oral Sci. 2010;18:166–170. - PMC - PubMed
    1. Brancher JA, Pecharki GD, Doetzer AD, Medeitors KG, Cordeiro CA, JR, Sotomaior VS, Bauer P, Trevilatto PC. Analysis of polymorphisms in the lactotransferrin gene promoter and dental caries. Int J Dent. 2011;2011:571726. - PMC - PubMed
    1. Briseño-Ruiz J, Shimizu T, Deeley K, Dizak PM, Ruff TD, Faraco IM, Jr, Poletta FA, Brancher JA, Pecharki GD, Küchler EC, Tannure PN, Lips A, Vieira TC, Patir A, Koruyucu M, Mereb JC, Resick JM, Brandon CA, Letra A, Silva RM, Cooper ME, Seymen F, Costa MC, Granjeiro JM, Trevilatto PC, Orioli IM, Castilla EE, Marazita ML, Vieira AR. Role of TRAV locus in low caries experience. Hum Genet. 2013 May 9; Epub ahead of print. - PMC - PubMed
    1. Caufield PW, Cutter GR, Dasanayake AP. Initial acquisition of mutans streptococci by infants: evidence for a discrete window of infectivity. J Dent Res. 1993;72:37–45. - PubMed

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