doi: 10.1038/338039a0.
Transcription activation by the adenovirus E1a protein
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- PMID: 2521923
- DOI: 10.1038/338039a0
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Transcription activation by the adenovirus E1a protein
Nature.
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Abstract
The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.
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