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Practice Guideline
. 2013 Dec;94(6):640-5.
doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29.

Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing

K E Caudle  1 , C F Thorn, T E Klein, J J Swen, H L McLeod, R B Diasio, M Schwab
Affiliations
Practice Guideline

Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing

K E Caudle et al. Clin Pharmacol Ther. 2013 Dec.

Abstract

The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. Detoxifying metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene), and reduced or absent activity of this enzyme can result in severe, and sometimes fatal, toxicity. We summarize evidence from the published literature supporting this association and provide dosing recommendations for fluoropyrimidines based on DPYD genotype (updates at http://www.pharmgkb.org).

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