Pathways of antigen processing
- PMID: 23298205
- PMCID: PMC4026165
- DOI: 10.1146/annurev-immunol-032712-095910
Pathways of antigen processing
Abstract
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar processing of self proteins is necessary to establish and maintain tolerance. Cells use a variety of mechanisms to acquire protein antigens, from translation in the cytosol to variations on the theme of endocytosis, and to degrade them once acquired. In this review, we highlight the aspects of MHC-I and MHC-II biosynthesis and assembly that have evolved to intersect these pathways and sample the peptides that are produced.
Figures




Similar articles
-
Peptides bound to major histocompatibility complex molecules.Peptides. 1998;19(1):179-98. doi: 10.1016/s0196-9781(97)00277-5. Peptides. 1998. PMID: 9437752 Review.
-
Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipoprotein, CpG DNA, and lipopolysaccharide.J Immunol. 2003 Aug 1;171(3):1413-22. doi: 10.4049/jimmunol.171.3.1413. J Immunol. 2003. PMID: 12874233
-
Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition.J Immunol. 1999 Nov 15;163(10):5201-10. J Immunol. 1999. PMID: 10553040
-
Contrasting efficacy of presentation by major histocompatibility complex class I and class II products when peptides are administered within a common protein carrier, self immunoglobulin.Eur J Immunol. 1993 Nov;23(11):2746-50. doi: 10.1002/eji.1830231104. Eur J Immunol. 1993. PMID: 8223850
-
Autophagy and its role in MHC-mediated antigen presentation.J Immunol. 2009 Mar 15;182(6):3335-41. doi: 10.4049/jimmunol.0803458. J Immunol. 2009. PMID: 19265109 Free PMC article. Review.
Cited by
-
B.1.1.7 (Alpha) variant is the most antigenic compared to Wuhan strain, B.1.351, B.1.1.28/triple mutant and B.1.429 variants.Front Microbiol. 2022 Aug 12;13:895695. doi: 10.3389/fmicb.2022.895695. eCollection 2022. Front Microbiol. 2022. PMID: 36033846 Free PMC article.
-
Microneedle Delivery of an Adjuvanted Microparticulate Vaccine Induces High Antibody Levels in Mice Vaccinated against Coronavirus.Vaccines (Basel). 2022 Sep 7;10(9):1491. doi: 10.3390/vaccines10091491. Vaccines (Basel). 2022. PMID: 36146568 Free PMC article.
-
TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap.Nat Commun. 2021 May 26;12(1):3174. doi: 10.1038/s41467-021-23225-6. Nat Commun. 2021. PMID: 34039964 Free PMC article.
-
Microbe-inducible trafficking pathways that control Toll-like receptor signaling.Traffic. 2017 Jan;18(1):6-17. doi: 10.1111/tra.12454. Epub 2016 Nov 23. Traffic. 2017. PMID: 27731905 Free PMC article. Review.
-
Chickens as a simple system for scientific discovery: The example of the MHC.Mol Immunol. 2021 Jul;135:12-20. doi: 10.1016/j.molimm.2021.03.019. Epub 2021 Apr 9. Mol Immunol. 2021. PMID: 33845329 Free PMC article.
References
-
- Cohen NR, Garg S, Brenner MB. Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Adv Immunol. 2009;102:1–94. - PubMed
-
- Adams E. Biology and Structure of Nonclassical MHC Class I Molecules. Ann Rev. Immunol. 2013 in press. - PubMed
-
- Watts C. The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules. Nat Immunol. 2004;5:685–92. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01 AI059167/AI/NIAID NIH HHS/United States
- R01 AI097206/AI/NIAID NIH HHS/United States
- U01 DK085505/DK/NIDDK NIH HHS/United States
- HHMI/Howard Hughes Medical Institute/United States
- R01AI069085/AI/NIAID NIH HHS/United States
- U01DK085505/DK/NIDDK NIH HHS/United States
- R56 AI049589/AI/NIAID NIH HHS/United States
- R01AI059167/AI/NIAID NIH HHS/United States
- R01 AI079065/AI/NIAID NIH HHS/United States
- P01 AI056097/AI/NIAID NIH HHS/United States
- R01 AI069085/AI/NIAID NIH HHS/United States
- R01AI097206/AI/NIAID NIH HHS/United States
- R01AI079065/AI/NIAID NIH HHS/United States
- P01 AI084853/AI/NIAID NIH HHS/United States
- P01AI084853/AI/NIAID NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials