Eosinophils: changing perspectives in health and disease
- PMID: 23154224
- PMCID: PMC4357492
- DOI: 10.1038/nri3341
Eosinophils: changing perspectives in health and disease
Abstract
Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector cells. Recent studies have profoundly altered this simplistic view of eosinophils and their function. New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved our understanding of the immunomodulatory functions of these cells and their roles in promoting homeostasis. Likewise, recent developments have generated a more sophisticated view of how eosinophils contribute to the pathogenesis of different diseases, including asthma and primary hypereosinophilic syndromes, and have also provided us with a more complete appreciation of the activities of these cells during parasitic infection.
Conflict of interest statement
The authors declare no competing financial interests.
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Comment in
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Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues.Nat Rev Immunol. 2013 Dec;13(12):902. doi: 10.1038/nri3341-c1. Nat Rev Immunol. 2013. PMID: 24270781 No abstract available.
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Reply to eosinophil cytolysis and release of cell-free granules.Nat Rev Immunol. 2013 Dec;13(12):902. doi: 10.1038/nri3341-c2. Nat Rev Immunol. 2013. PMID: 24270783 No abstract available.
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