Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting
- PMID: 21159652
- DOI: 10.1158/0008-5472.CAN-10-2341
Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting
Abstract
Paxillin (PXN) gene mutations are associated with lung adenocarcinoma progression and PXN is known to be a target gene of microRNA-218 (miR-218). On this basis, we hypothesized that PXN overexpression via miR-218 suppression may promote tumor progression and metastasis and that PXN may predict survival and relapse in non-small cell lung cancer (NSCLC). Expression of miR-218 and PXN in 124 surgically resected lung tumors were evaluated by real-time PCR and immunohistochemical analysis. The prognostic value of miR-218 and PXN expression on overall survival (OS) and relapse-free survival (RFS) was analyzed by the Kaplan-Meier test and Cox regression analysis. miR-218 expression in lung tumors was negatively associated with PXN expression. Multivariate analyses showed that PXN and miR-218 might independently predict OS and RFS, respectively, in NSCLC. Moreover, patients with low miR-218 combined with PXN-positive had the worst OS and RFS among the 4 combinations. In a cell model, PXN was negatively regulated by miR-218 and cell proliferation, invasion, and soft agar colony formation were enhanced by PXN overexpression induced by miR-218 suppression. Taken together, our findings suggest that PXN overexpression induced by miR-218 suppression is an independent predictor of survival and relapse in NSCLC, highlighting PXN as a potential therapeutic target to improve clinical outcomes in this disease.
©2010 AACR.
Similar articles
-
Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting.Carcinogenesis. 2014 Aug;35(8):1823-9. doi: 10.1093/carcin/bgu102. Epub 2014 Apr 29. Carcinogenesis. 2014. PMID: 24894864
-
MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc.Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1532-9. doi: 10.1245/s10434-015-4595-z. Epub 2015 May 20. Ann Surg Oncol. 2015. PMID: 25990966
-
Reduced XPC messenger RNA level may predict a poor outcome of patients with nonsmall cell lung cancer.Cancer. 2007 Jul 1;110(1):215-23. doi: 10.1002/cncr.22743. Cancer. 2007. PMID: 17508409
-
High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer.Eur J Cancer. 2013 Feb;49(3):604-15. doi: 10.1016/j.ejca.2012.09.031. Epub 2012 Oct 22. Eur J Cancer. 2013. PMID: 23099007 Review.
-
The biology and management of non-small cell lung cancer.Nature. 2018 Jan 24;553(7689):446-454. doi: 10.1038/nature25183. Nature. 2018. PMID: 29364287 Review.
Cited by
-
MiR-218-5p/EGFR Signaling in Arsenic-Induced Carcinogenesis.Cancers (Basel). 2023 Feb 14;15(4):1204. doi: 10.3390/cancers15041204. Cancers (Basel). 2023. PMID: 36831545 Free PMC article.
-
Deregulation of the miRNAs expression in cervical cancer: human papillomavirus implications.Biomed Res Int. 2013;2013:407052. doi: 10.1155/2013/407052. Epub 2013 Dec 31. Biomed Res Int. 2013. PMID: 24490161 Free PMC article. Review.
-
Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinoma.Ups J Med Sci. 2014 Nov;119(4):324-32. doi: 10.3109/03009734.2014.960053. Epub 2014 Sep 18. Ups J Med Sci. 2014. PMID: 25231007 Free PMC article.
-
POU2F2-oriented network promotes human gastric cancer metastasis.Gut. 2016 Sep;65(9):1427-38. doi: 10.1136/gutjnl-2014-308932. Epub 2015 May 27. Gut. 2016. PMID: 26019213 Free PMC article.
-
MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.Mol Med Rep. 2015 Jul;12(1):1016-22. doi: 10.3892/mmr.2015.3516. Epub 2015 Mar 19. Mol Med Rep. 2015. PMID: 25816091 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical