Monocyte-derived dendritic cells in innate and adaptive immunity
- PMID: 18362945
- DOI: 10.1038/icb.2008.14
Monocyte-derived dendritic cells in innate and adaptive immunity
Abstract
Monocytes have been classically considered essential elements in relation with innate immune responses against pathogens, and inflammatory processes caused by external aggressions, infection and autoimmune disease. However, although their potential to differentiate into dendritic cells (DCs) was discovered 14 years ago, their functional relevance with regard to adaptive immune responses has only been uncovered very recently. Studies performed over the last years have revealed that monocyte-derived DCs play an important role in innate and adaptive immunity, due to their microbicidal potential, capacity to stimulate CD4(+) and CD8(+) T-cell responses and ability to regulate Immunoglobulin production by B cells. In addition, monocyte-derived DCs not only constitute a subset of DCs formed at inflammatory foci, as previously thought, but also comprise different subsets of DCs located in antigen capture areas, such as the skin and the intestinal, respiratory and reproductive tracts.
Similar articles
-
Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation.Immunol Rev. 2010 Mar;234(1):90-104. doi: 10.1111/j.0105-2896.2009.00876.x. Immunol Rev. 2010. PMID: 20193014 Review.
-
Insights how monocytes and dendritic cells contribute and regulate immune defense against microbial pathogens.Immunobiology. 2015 Feb;220(2):215-26. doi: 10.1016/j.imbio.2014.10.025. Epub 2014 Oct 31. Immunobiology. 2015. PMID: 25468558 Review.
-
Monocyte-derived dendritic cells.Semin Immunol. 2005 Aug;17(4):313-8. doi: 10.1016/j.smim.2005.05.013. Semin Immunol. 2005. PMID: 15955712 Review.
-
Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania.Immunity. 2007 Apr;26(4):519-31. doi: 10.1016/j.immuni.2007.01.017. Epub 2007 Apr 5. Immunity. 2007. PMID: 17412618
-
Role of inflammatory dendritic cells in innate and adaptive immunity.Eur J Immunol. 2012 Oct;42(10):2535-43. doi: 10.1002/eji.201242480. Eur J Immunol. 2012. PMID: 23042650 Review.
Cited by
-
Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling.Cell Commun Signal. 2012 Aug 1;10(1):22. doi: 10.1186/1478-811X-10-22. Cell Commun Signal. 2012. PMID: 22852877 Free PMC article.
-
Innate B cell helpers reveal novel types of antibody responses.Nat Immunol. 2013 Feb;14(2):119-26. doi: 10.1038/ni.2511. Epub 2013 Jan 18. Nat Immunol. 2013. PMID: 23334833 Review.
-
Advancements in Host-Based Interventions for Influenza Treatment.Front Immunol. 2018 Jul 10;9:1547. doi: 10.3389/fimmu.2018.01547. eCollection 2018. Front Immunol. 2018. PMID: 30042762 Free PMC article. Review.
-
Dendritic Cells and Their Role in Allergy: Uptake, Proteolytic Processing and Presentation of Allergens.Int J Mol Sci. 2017 Jul 11;18(7):1491. doi: 10.3390/ijms18071491. Int J Mol Sci. 2017. PMID: 28696399 Free PMC article. Review.
-
Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells.Nat Commun. 2017 Oct 24;8(1):1109. doi: 10.1038/s41467-017-01015-3. Nat Commun. 2017. PMID: 29061960 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
