MHC class II molecules on the move for successful antigen presentation
- PMID: 18046453
- PMCID: PMC2206127
- DOI: 10.1038/sj.emboj.7601945
MHC class II molecules on the move for successful antigen presentation
Abstract
Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in these compartments. MHC II acquire antigenic fragments from endocytosed proteins for presentation at the cell surface. In a unique and complex series of reactions, MHC II succeed in exchanging a remaining fragment of Ii for other protein fragments in subdomains of MIIC before transport to the cell surface. Here, the mechanisms regulating loading and intracellular trafficking of MHC II are discussed.
Figures


Similar articles
-
Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments.J Cell Biol. 1997 Nov 3;139(3):639-49. doi: 10.1083/jcb.139.3.639. J Cell Biol. 1997. PMID: 9348281 Free PMC article.
-
The ins and outs of MHC class II-mediated antigen processing and presentation.Nat Rev Immunol. 2015 Apr;15(4):203-16. doi: 10.1038/nri3818. Epub 2015 Feb 27. Nat Rev Immunol. 2015. PMID: 25720354 Free PMC article. Review.
-
Role of the major histocompatibility complex class II transmembrane region in antigen presentation and intracellular trafficking.Immunology. 2004 Feb;111(2):165-72. doi: 10.1111/j.0019-2805.2003.01772.x. Immunology. 2004. PMID: 15027901 Free PMC article.
-
Intracellular transport of MHC class II molecules.Immunol Today. 1992 May;13(5):179-84. doi: 10.1016/0167-5699(92)90123-O. Immunol Today. 1992. PMID: 1642756 Review.
-
A central role for HSC70 in regulating antigen trafficking and MHC class II presentation.Mol Immunol. 2015 Dec;68(2 Pt A):85-8. doi: 10.1016/j.molimm.2015.04.007. Epub 2015 May 4. Mol Immunol. 2015. PMID: 25953005 Free PMC article. Review.
Cited by
-
Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis.Brain. 2015 Jun;138(Pt 6):1531-47. doi: 10.1093/brain/awv080. Epub 2015 Mar 29. Brain. 2015. PMID: 25823473 Free PMC article.
-
Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease.Chem Asian J. 2012 May;7(5):992-9. doi: 10.1002/asia.201101041. Epub 2012 Mar 12. Chem Asian J. 2012. PMID: 22411856 Free PMC article.
-
Cross-Protection against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and Protein.J Virol. 2020 Nov 23;94(24):e01176-20. doi: 10.1128/JVI.01176-20. Print 2020 Nov 23. J Virol. 2020. PMID: 32967955 Free PMC article.
-
The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.iScience. 2019 Jan 25;11:160-177. doi: 10.1016/j.isci.2018.12.015. Epub 2018 Dec 20. iScience. 2019. PMID: 30612035 Free PMC article.
-
Cathepsin S, a new serum biomarker of sarcoidosis discovered by transcriptome analysis of alveolar macrophages.Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(2):141-147. doi: 10.36141/svdld.v36i2.7620. Epub 2019 May 1. Sarcoidosis Vasc Diffuse Lung Dis. 2019. PMID: 32476947 Free PMC article.
References
-
- Bakke O, Dobberstein B (1990) MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63: 707–716 - PubMed
-
- Blander JM, Medzhitov R (2006) Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 440: 808–812 - PubMed
-
- Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL (2002) T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418: 983–988 - PubMed
-
- Brown CL, Maier KC, Stauber T, Ginkel LM, Wordeman L, Vernos I, Schroer TA (2005) Kinesin-2 is a motor for late endosomes and lysosomes. Traffic 6: 1114–1124 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials