Tobacco smoking and autoimmune rheumatic diseases
- PMID: 18037930
- DOI: 10.1038/ncprheum0655
Tobacco smoking and autoimmune rheumatic diseases
Abstract
Autoimmune rheumatic diseases are considered to be influenced by both genetic and environmental factors. Tobacco smoking has been linked to the development of rheumatic diseases, namely systemic lupus erythematosus and rheumatoid arthritis, and has been shown to interact with genetic factors to create a significant combined risk of disease. Smoking also affects both the course and the outcome of rheumatic diseases. Smoking increases the risk of dermatologic features and nephritis in systemic lupus erythematosus, rheumatoid nodules and multiple joint involvement in rheumatoid arthritis and digital ischemia in systemic sclerosis, as well as further increasing the risk of accelerated atherosclerosis in these diseases. Smoking is known to modulate the immune system through many mechanisms, including the induction of the inflammatory response, immune suppression, alteration of cytokine balance, induction of apoptosis, and DNA damage that results in the formation of anti-DNA antibodies. No sole mechanism, however, has been linked to any of the autoimmune illnesses, which therefore complicates full comprehension of the 'smoking effect'. Further studies, perhaps using animal models, are needed to analyze the exact effect of smoking on each disease separately.
Similar articles
-
Smoking as a trigger for inflammatory rheumatic diseases.Curr Opin Rheumatol. 2007 Jan;19(1):49-54. doi: 10.1097/BOR.0b013e32801127c8. Curr Opin Rheumatol. 2007. PMID: 17143096 Review.
-
[Autoimmune changes in various rheumatic diseases].Ter Arkh. 1986;58(7):43-6. Ter Arkh. 1986. PMID: 3490009 Russian.
-
[Immunopathology of collagen diseases].Klin Med (Mosk). 1974 Jan;52(1):20-30. Klin Med (Mosk). 1974. PMID: 4157037 Review. Russian. No abstract available.
-
Prevention of autoimmune rheumatic disease: state of the art and future perspectives.Ann Rheum Dis. 2010 Dec;69(12):2062-6. doi: 10.1136/ard.2010.142109. Ann Rheum Dis. 2010. PMID: 21097657 Review.
-
[Natural biological models of autoimmune diseases].Revmatologiia (Mosk). 1991 Oct-Dec;(4):38-44. Revmatologiia (Mosk). 1991. PMID: 1805332 Review. Russian. No abstract available.
Cited by
-
VEGF Profile in Early Undifferentiated Arthritis Cohort.Medicina (Kaunas). 2022 Jun 20;58(6):833. doi: 10.3390/medicina58060833. Medicina (Kaunas). 2022. PMID: 35744097 Free PMC article.
-
Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Women's Health Initiative Observational Cohort.J Clin Rheumatol. 2019 Apr;25(3):127-132. doi: 10.1097/RHU.0000000000000788. J Clin Rheumatol. 2019. PMID: 29794514 Free PMC article.
-
Immune Dysregulation in Cancer Patients Undergoing Immune Checkpoint Inhibitor Treatment and Potential Predictive Strategies for Future Clinical Practice.Front Oncol. 2018 Mar 22;8:80. doi: 10.3389/fonc.2018.00080. eCollection 2018. Front Oncol. 2018. PMID: 29623257 Free PMC article. Review.
-
Sex-Specific Associations Between Serum Lipids, Antinuclear Antibodies, and Statin Use in National Health and Nutrition Examination Surveys 1999-2004.Front Med (Lausanne). 2022 May 26;9:887741. doi: 10.3389/fmed.2022.887741. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35721098 Free PMC article.
-
Smoking: effects on multiple sclerosis susceptibility and disease progression.Ther Adv Neurol Disord. 2012 Jan;5(1):13-22. doi: 10.1177/1756285611425694. Ther Adv Neurol Disord. 2012. PMID: 22276073 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical