doi: 10.1016/j.tig.2007.08.015.
Epub 2007 Oct 26.
Crossover interference underlies sex differences in recombination rates
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- PMID: 17964681
- DOI: 10.1016/j.tig.2007.08.015
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Crossover interference underlies sex differences in recombination rates
Trends Genet.
2007 Nov.
Abstract
In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.
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