Review
doi: 10.1016/j.canlet.2007.09.004.
Epub 2007 Oct 18.
Targeting the neural cell adhesion molecule in cancer
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- PMID: 17949897
- DOI: 10.1016/j.canlet.2007.09.004
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Review
Targeting the neural cell adhesion molecule in cancer
Cancer Lett.
.
Abstract
NCAM is a tumour associated antigen expressed on small cell lung cancer, neuroblastoma, rhabdomyosarkoma, brain tumours, multiple myelomas and acute myeloid leukaemia. Constant and strong expression of NCAM is a prerequisite for the development of antibody-based immunotherapies. From the spectrum of existing anti-NCAM compounds, radioimmunoconjugates and immunotoxins represent the clinically most advanced and successful strategies. Here we provide an overview of the evolving field of anti-NCAM immunotherapy for cancer and discuss its indications and limitations.
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