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. 2007 Nov 16;318(5853):1108-13.
doi: 10.1126/science.1145720. Epub 2007 Oct 11.

The genomic landscapes of human breast and colorectal cancers

Laura D Wood  1 , D Williams Parsons, Siân Jones, Jimmy Lin, Tobias Sjöblom, Rebecca J Leary, Dong Shen, Simina M Boca, Thomas Barber, Janine Ptak, Natalie Silliman, Steve Szabo, Zoltan Dezso, Vadim Ustyanksky, Tatiana Nikolskaya, Yuri Nikolsky, Rachel Karchin, Paul A Wilson, Joshua S Kaminker, Zemin Zhang, Randal Croshaw, Joseph Willis, Dawn Dawson, Michail Shipitsin, James K V Willson, Saraswati Sukumar, Kornelia Polyak, Ben Ho Park, Charit L Pethiyagoda, P V Krishna Pant, Dennis G Ballinger, Andrew B Sparks, James Hartigan, Douglas R Smith, Erick Suh, Nickolas Papadopoulos, Phillip Buckhaults, Sanford D Markowitz, Giovanni Parmigiani, Kenneth W Kinzler, Victor E Velculescu, Bert Vogelstein
Affiliations

The genomic landscapes of human breast and colorectal cancers

Laura D Wood et al. Science. .

Abstract

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.

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  • Cancer. The gene topography of cancer.
    Trent JM, Touchman JW. Trent JM, et al. Science. 2007 Nov 16;318(5853):1079-80. doi: 10.1126/science.1151428. Science. 2007. PMID: 18006731 No abstract available.

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