Phagocytosis: elegant complexity
- PMID: 15894272
- DOI: 10.1016/j.immuni.2005.05.002
Phagocytosis: elegant complexity
Abstract
Phagocytosis requires receptor-mediated recognition of particles, usually in the guise of infectious agents and apoptotic cells. Phagosomes fuse with lysosomes to generate phagolysosomes, which play a key role in enzymatic digestion of the internalized contents into component parts. Recent findings indicate that a simple paradigm of a single cognate receptor interaction that guides the phagosome to phagolysosome formation belies the complexity of combinatorial receptor recognition and diversity of phagosome function. In fact, phagosomes are comprised of hundreds of proteins that play a key role in deciphering the contents of the phagosome and in defining host response. In this review we discuss how the challenge of recognizing diverse molecular patterns is met by combinatorial interactions between phagocytic receptors. Furthermore, these combinations are dynamic and both sculpt the balance between a proinflammatory or anti-inflammatory response and direct phagosome diversity. We also indicate an important role for genetically tractable model organisms in defining key components of this evolutionarily conserved process.
Similar articles
-
A systems biology analysis of the Drosophila phagosome.Nature. 2007 Jan 4;445(7123):95-101. doi: 10.1038/nature05380. Epub 2006 Dec 6. Nature. 2007. PMID: 17151602
-
[Role of phagocytosis in infectious disease: overview].Tanpakushitsu Kakusan Koso. 2006 Feb;51(2):101-6. Tanpakushitsu Kakusan Koso. 2006. PMID: 16457200 Review. Japanese. No abstract available.
-
Phagocytosis of optically-trapped particles: delivery of the pure phagocytic signal.Cell Res. 2006 Nov;16(11):852-4. doi: 10.1038/sj.cr.7310105. Cell Res. 2006. PMID: 17109010 No abstract available.
-
Phagosome dynamics and function.Bioessays. 2000 Mar;22(3):255-63. doi: 10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R. Bioessays. 2000. PMID: 10684585 Review.
-
Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis.Eur J Cell Biol. 2010 Sep;89(9):693-704. doi: 10.1016/j.ejcb.2010.04.006. Epub 2010 Jun 25. Eur J Cell Biol. 2010. PMID: 20579766
Cited by
-
Multiple Origins of Extracellular DNA Traps.Front Immunol. 2021 Feb 24;12:621311. doi: 10.3389/fimmu.2021.621311. eCollection 2021. Front Immunol. 2021. PMID: 33717121 Free PMC article. Review.
-
Laparotomy and laparoscopy diversely affect macrophage-associated antimicrobial activity in a murine model.BMC Immunol. 2013 Jun 20;14:27. doi: 10.1186/1471-2172-14-27. BMC Immunol. 2013. PMID: 23786397 Free PMC article.
-
Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers.Pharmaceutics. 2021 Mar 22;13(3):428. doi: 10.3390/pharmaceutics13030428. Pharmaceutics. 2021. PMID: 33809969 Free PMC article. Review.
-
Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease.Int J Alzheimers Dis. 2012;2012:489456. doi: 10.1155/2012/489456. Epub 2012 May 15. Int J Alzheimers Dis. 2012. PMID: 22666621 Free PMC article.
-
IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways.EMBO J. 2006 Jun 21;25(12):2878-88. doi: 10.1038/sj.emboj.7601170. Epub 2006 Jun 8. EMBO J. 2006. PMID: 16763563 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
