Antibacterial activity of hydrolyzable tannins derived from medicinal plants against Helicobacter pylori
- PMID: 15107535
- DOI: 10.1111/j.1348-0421.2004.tb03521.x
Antibacterial activity of hydrolyzable tannins derived from medicinal plants against Helicobacter pylori
Abstract
Helicobacter pylori is a major etiological agent in gastroduodenal disorders. In this study, we isolated 36 polyphenols and 4 terpenoids from medicinal plants, and investigated their antibacterial activity against H. pylori in vitro. All hydrolyzable tannins tested demonstrated promising antibacterial activity against H. pylori. Monomeric hydrolyzable tannins revealed especially strong activity. Other compounds demonstrated minimal antibacterial activity with a few exceptions. A monomeric hydrolyzable tannin, Tellimagrandin I demonstrated time- and dose-dependent bactericidal activity against H. pylori in vitro. On the other hand, hydrolyzable tannins did not affect the viability of MKN-28 cells derived from human gastric epithelium. Hydrolyzable tannins, therefore, have potential as new and safe therapeutic regimens against H. pylori infection. Furthermore, we investigated effects of hydrolyzable tannins on lipid bilayer membranes. All the hydrolyzable tannins tested demonstrated dose-dependent membrane-damaging activity. However, it remains to be elucidated whether their membrane-damaging activity directly contributes to their antibacterial action.
Similar articles
-
Hydrolyzable tannins and related polyphenols from Eucalyptus globulus.J Asian Nat Prod Res. 2000;2(3):205-12. doi: 10.1080/10286020008039912. J Asian Nat Prod Res. 2000. PMID: 11256694
-
Chemistry and function of vegetable polyphenols with high molecular weights.Biofactors. 2000;13(1-4):121-5. doi: 10.1002/biof.5520130120. Biofactors. 2000. PMID: 11237170 Review.
-
Anti-Helicobacter pylori compounds from the ethanol extracts of Geranium wilfordii.J Ethnopharmacol. 2013 May 2;147(1):204-7. doi: 10.1016/j.jep.2013.02.032. Epub 2013 Mar 7. J Ethnopharmacol. 2013. PMID: 23500884
-
Antimicrobial activity of an Amazon medicinal plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria.Phytother Res. 2012 Jun;26(6):791-9. doi: 10.1002/ptr.3646. Epub 2011 Oct 28. Phytother Res. 2012. PMID: 22034238
-
[Review in the studies on tannins activity of cancer prevention and anticancer].Zhong Yao Cai. 2003 Jun;26(6):444-8. Zhong Yao Cai. 2003. PMID: 14528687 Review. Chinese.
Cited by
-
Ellagitannin HeT obtained from strawberry leaves is oxidized by bacterial membranes and inhibits the respiratory chain.FEBS Open Bio. 2018 Jan 4;8(2):211-218. doi: 10.1002/2211-5463.12361. eCollection 2018 Feb. FEBS Open Bio. 2018. PMID: 29435411 Free PMC article.
-
Protective Effect of Polyphenolic Extracts from Hippophae rhamnoides L. and Reynoutria japonica Houtt. on Erythrocyte Membrane.Molecules. 2024 Jun 28;29(13):3090. doi: 10.3390/molecules29133090. Molecules. 2024. PMID: 38999046 Free PMC article.
-
Effect of Hydrolysable Tannins and Anthocyanins on Recurrent Urinary Tract Infections in Nephropathic Patients: Preliminary Data.Nutrients. 2021 Feb 11;13(2):591. doi: 10.3390/nu13020591. Nutrients. 2021. PMID: 33670236 Free PMC article.
-
Effect of Byrsonima crassa and phenolic constituents on Helicobacter pylori-induced neutrophils oxidative burst.Int J Mol Sci. 2012;13(1):133-41. doi: 10.3390/ijms13010133. Epub 2011 Dec 23. Int J Mol Sci. 2012. PMID: 22312243 Free PMC article.
-
Anti-Helicobacter pylori potential of artemisinin and its derivatives.Antimicrob Agents Chemother. 2012 Sep;56(9):4594-607. doi: 10.1128/AAC.00407-12. Epub 2012 Jun 11. Antimicrob Agents Chemother. 2012. PMID: 22687518 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
