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. 2001 Dec 28;26(6):543-5.

[Expression of the neural cell adhesion molecule in human astrocytomas]

[Article in Chinese]
C X Huang  1 , S X Hu, B Chen
Affiliations
  • PMID: 12536535

[Expression of the neural cell adhesion molecule in human astrocytomas]

[Article in Chinese]
C X Huang et al. Hunan Yi Ke Da Xue Xue Bao. .

Abstract

Objective: To investigate the expression of the neural cell adhesion molecule (NCAM) in human astrocytomas, and evaluate the relationship between NCAM and proliferating cell nuclear antigen (PCNA).

Methods: Forty-eight astrocytomas were studied by SP method with monoclonal antibody against NCAM and PCNA proteins.

Results: All normal brain tissues expressed NCAM; NCAM expression was positive in Grade I-II glioma [95% (19/20)], Grade III glioma [38.9% (7/18)], Grade IV glioma [20% (2/10)] respectively. An inverse correlation was observed between the degree of NCAM expression and that of PCNA (r = -0.657, P < 0.05).

Conclusion: NCAM is a down-regulated factor in the development of the malignancy of astrocytomas; and it is suggested that the reduced NCAM expression might be involved in the development of biological malignancy.

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