Dynamin: characteristics, mechanism of action and function
- PMID: 12511974
Dynamin: characteristics, mechanism of action and function
Abstract
Dynamin - a member of the GTP-ase protein family - is essential for many intracellular membrane trafficking events in multiple endocytic processes. The unique biochemical features of dynamin - especially its propensity to assemble - enable severing the nascent vesicles from the membrane. The mechanism of dynamin's action is still a subject of debate - whether it functions as a mechanochemical enzyme or a regulatory GTPase. The GTPase domain of dynamin contains three GTP-binding motifs. This domain is very conservative across the species, including that recently cloned by us in the unicellular eukaryote Paramecium. Dynamin interacts with a number of partners such as endophilin and proteins involved in coordination of endocytosis with motor molecules. A growing body of evidence indicates that dynamin and dynamin-related proteins are involved both in pathology and protection against human diseases. The most interesting are dynamin-like Mx proteins exhibiting antiviral activity.
Similar articles
-
Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis.Nature. 1999 Apr 8;398(6727):481-6. doi: 10.1038/19024. Nature. 1999. PMID: 10206643
-
GTPase activity of dynamin and resulting conformation change are essential for endocytosis.Nature. 2001 Mar 8;410(6825):231-5. doi: 10.1038/35065645. Nature. 2001. PMID: 11242086
-
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring.Nat Cell Biol. 1999 May;1(1):27-32. doi: 10.1038/8997. Nat Cell Biol. 1999. PMID: 10559860
-
Dynamin and its role in membrane fission.Annu Rev Cell Dev Biol. 2000;16:483-519. doi: 10.1146/annurev.cellbio.16.1.483. Annu Rev Cell Dev Biol. 2000. PMID: 11031245 Free PMC article. Review.
-
Dynamin, a membrane-remodelling GTPase.Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88. doi: 10.1038/nrm3266. Nat Rev Mol Cell Biol. 2012. PMID: 22233676 Free PMC article. Review.
Cited by
-
Vps1 in the late endosome-to-vacuole traffic.J Biosci. 2013 Mar;38(1):73-83. doi: 10.1007/s12038-012-9295-2. J Biosci. 2013. PMID: 23385815
-
The transcriptome of utricle hair cell regeneration in the avian inner ear.J Neurosci. 2014 Mar 5;34(10):3523-35. doi: 10.1523/JNEUROSCI.2606-13.2014. J Neurosci. 2014. PMID: 24599453 Free PMC article.
-
Molecular regulation of osteoclast activity.Rev Endocr Metab Disord. 2006 Jun;7(1-2):123-39. doi: 10.1007/s11154-006-9009-x. Rev Endocr Metab Disord. 2006. PMID: 16951988 Review.
-
Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.Methods Enzymol. 2008;438:77-93. doi: 10.1016/S0076-6879(07)38006-3. Methods Enzymol. 2008. PMID: 18413242 Free PMC article.
-
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5114-22. doi: 10.1073/pnas.1414298111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385580 Free PMC article.