Review
doi: 10.1016/s0959-437x(00)00161-1.
Mitotic checkpoints: from yeast to cancer
Affiliations
- PMID: 11163156
- DOI: 10.1016/s0959-437x(00)00161-1
Item in Clipboard
Review
Mitotic checkpoints: from yeast to cancer
Curr Opin Genet Dev.
2001 Feb.
Abstract
Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.
Similar articles
-
The control of mitosis.Front Biosci. 2000 Jan 1;5:D50-7. doi: 10.2741/hixon. Front Biosci. 2000. PMID: 10702375 Review.
-
Monitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.Cell Prolif. 2011 Oct;44(5):391-400. doi: 10.1111/j.1365-2184.2011.00767.x. Cell Prolif. 2011. PMID: 21951282 Free PMC article. Review.
-
Anaphase onset does not require the microtubule-dependent depletion of kinetochore and centromere-binding proteins.J Cell Sci. 2002 Oct 1;115(Pt 19):3787-95. doi: 10.1242/jcs.00057. J Cell Sci. 2002. PMID: 12235289
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.J Cell Biol. 2003 Apr 28;161(2):267-80. doi: 10.1083/jcb.200208091. J Cell Biol. 2003. PMID: 12719470 Free PMC article.
-
Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.Mol Biol Cell. 2007 Mar;18(3):850-63. doi: 10.1091/mbc.e06-07-0587. Epub 2006 Dec 20. Mol Biol Cell. 2007. PMID: 17182852 Free PMC article.
Cited by
-
TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis.Sci Rep. 2016 Jul 11;6:29735. doi: 10.1038/srep29735. Sci Rep. 2016. PMID: 27405720 Free PMC article.
-
Spindle checkpoint and apoptotic response in alpha-particle transformed human bronchial epithelial cells.Radiat Environ Biophys. 2004 Dec;43(4):257-63. doi: 10.1007/s00411-004-0268-1. Epub 2004 Dec 18. Radiat Environ Biophys. 2004. PMID: 15609016
-
An overview of Cdk1-controlled targets and processes.Cell Div. 2010 May 13;5:11. doi: 10.1186/1747-1028-5-11. Cell Div. 2010. PMID: 20465793 Free PMC article.
-
Arsenic trioxide suppresses paclitaxel-induced mitotic arrest.Cell Prolif. 2009 Jun;42(3):404-11. doi: 10.1111/j.1365-2184.2009.00606.x. Epub 2009 Apr 24. Cell Prolif. 2009. PMID: 19397590 Free PMC article.
-
Structural and mechanistic insights into Mps1 kinase activation.J Cell Mol Med. 2009 Aug;13(8B):1679-1694. doi: 10.1111/j.1582-4934.2008.00605.x. J Cell Mol Med. 2009. PMID: 19120698 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
