CD154

CD154
	Renderização com base em PDB 1aly.
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1ALY, 1I9R, 3LKJ, 3QD6
Identificadores
Símbolos	CD40LG; CD154; CD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP; gp39; hCD40L
IDs externos	OMIM: 300386 MGI: 88337 HomoloGene: 56 GeneCards: CD40LG Gene
Ontologia do gene
Função molecular	•cytokine activity; •tumor necrosis factor receptor binding; •CD40 receptor binding;
Componente celular	•extracellular space; •membrana plasmática; •integral to plasma membrane; •external side of plasma membrane; •integral to membrane;
Processo biológico	•positive regulation of immune response to tumor cell; •anti-apoptosis; •resposta inflamatória; •leukocyte cell-cell adhesion; •platelet activation; •B cell differentiation; •positive regulation of B cell proliferation; •positive regulation of interferon-gamma production; •positive regulation of interleukin-10 production; •positive regulation of interleukin-12 production; •B cell proliferation; •isotype switching; •positive regulation of MHC class II biosynthetic process; •immunoglobulin secretion; •regulation of immune response; •regulation of immunoglobulin secretion; •positive regulation of endothelial cell apoptotic process;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

CD154 é uma proteína que é expressa primeiramente em células T activadas e é membro da superfamília TNF. Liga-se à CD40 em células apresentadoras de antigénios, o que leva a muitos efeitos dependendo do tipo de célula-alvo.

A proteína é expressa na superfície das células T.

Leitura de apoio

Parham, Peter (2004). The Immune System 2nd ed. [S.l.]: Garland Science. pp. 169–173. ISBN 0-8153-4093-1
Tong AW, Stone MJ (1997). «CD40 and the effect of anti-CD40-binding on human multiple myeloma clonogenicity.». Leuk. Lymphoma. 21 (1-2): 1–8. PMID 8907262. doi:10.3109/10428199609067572
van Kooten C, Banchereau J (2000). «CD40-CD40 ligand.». J. Leukoc. Biol. 67 (1): 2–17. PMID 10647992
Schattner EJ (2003). «CD40 ligand in CLL pathogenesis and therapy.». Leuk. Lymphoma. 37 (5-6): 461–72. PMID 11042507
Bhushan A, Covey LR (2002). «CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.». Immunol. Res. 24 (3): 311–24. PMID 11817328. doi:10.1385/IR:24:3:311
Cheng G, Schoenberger SP (2002). «CD40 signaling and autoimmunity.». Curr. Dir. Autoimmun. 5: 51–61. PMID 11826760
Subauste CS (2002). «CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection.». J. Infect. Dis. 185 Suppl 1: S83–9. PMID 11865444. doi:10.1086/338003
Kornbluth RS (2003). «An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection.». J. Hematother. Stem Cell Res. 11 (5): 787–801. PMID 12427285. doi:10.1089/152581602760404595
Xu Y, Song G (2005). «The role of CD40-CD154 interaction in cell immunoregulation.». J. Biomed. Sci. 11 (4): 426–38. PMID 15153777. doi:10.1159/000077892