The user can create or wield weaponry with the ability to counter and/or kill different types of creatures and entities. This ability is not only specific to mystic weapons, but also technologically advanced weapons. The power of the weapons depends on what they were created for or what level of killing potential they possess.
The Huntsclan (American Dragon: Jake Long) wield a variety of weapons for the purpose of slaying dragons and other magical creatures.
Anti-Sensei Bullets (Assassination Classroom) are just one of many weapons specifically designed to kill Korosensei.
The Stalker (Ben 10: Ultimate Alien) is equipped with countermeasures for all of Ben's Ultimatrix aliens, except Nanomech and Way Big.
Guts (Berserk) wields multiple weapons designed for the purpose of killing Apostles, their spawn, and even astral beings...
...such as his primary weapon the great slabsword, Dragonslayer...
...a cannon hand which can blow demons to pieces...
...and miniature spike bombs which can grievously wound Apostles.
Skull Knight's Sword of Resonance (Berserk) was forged for the purpose to kill Apostles and members of the God Hand.
Victor Freeman's (Blaster Knuckle) wields his titular weapon specifically to kill demons.
Kagan (BloodRayne) wields a sword forged from the Vesper Shard, glowing with solar energy that makes it deadly to vampires and dhampirs.
Django (Boktai) wields the Gun Del Sol, harnessing solar energy to make a deadly weapon against vampires and the undead.
Buffy Summers (Buffy the Vampire Slayer) wields a wide variety of different weapons to kill vampires and demons.
The Scythe (Buffy the Vampire Slayer) is an ancient weapon specifically designed for the Slayer to use against demons.
Simon Belmont (Castlevania) wielding the Vampire Killer, a whip capable of killing vampires, demons, and other creatures of darkness.
Gabriel Belmont/Dracula (Castlevania: Lords of Shadow) possesses the Vampire Killer, the greatest Combat Cross created by Rinaldo Gandolfi, modified with a chain whip forged of cast iron and drenched with holy water, a spiked chain to saw through wooden obstacles, and a wooden stake made specifically for killing vampires.
Trevor Belmont (Castlevania) wielding his family's legendary, Morning Star.
As an Accommodator, Allen Walker (D.Gray-man) wields Innocence, the only weapon/force capable of purifying Akuma and harming the Noah Family.
Nichirin Weapons (Demon Slayer: Kimetsu no Yaiba)...
...are the only weapons in the world capable of severely wounding and fully killing demons.
Genya Shinazugawa (Demon Slayer: Kimetsu no Yaiba) using his Nichirin shotgun to fire bullets made of Scarlet Crimson Iron Sand & Scarlet Ore to fight and kill demons.
Valerie Gray (Danny Phantom) possesses a wide variety of ghost hunting weaponry.
Lex Luthor (DC Comics) makes heavy use of Kryptonite weaponry to counter Kryptonians.
Batman (DC Comics) regularly uses different weapon types to handle different situations, such as a Kryptonite spear specifically to weaken and kill Superman...
...as well as Kryptonite gas grenades...
...and Red Sunlight particles...
...Nth metal knuckles to harm supernatural entities like the Gentleman Ghost...
...and garlic treated Batarangs to combat vampires like Dracula.
OMACs (DC Comics) are tailored for the specific purpose of counteracting and nullifying the abilities of any metahumans they encounter, adapting their weapons systems for that very purpose.
Hematic grenades (Death Stranding) are created from Sam's blood specifically to neutralize and destroy BTs.
Trunks (Dragon Ball Z) using the Brave Sword to wound Hirudegarn, severing his tail with ease.
WarGreymon and BlackWarGreymon (Digimon) both wield the Dramon Destroyers, special gauntlets that are particularly dangerous against Dramon-type Digimon.
Gray Fullbuster (Fairy Tail) uses Ice Devil Slayer Magic to create weapons of ice that harms demons.
Erza Scarlet (Fairy Tail enchanted Gray’s Ice Devil Slayer Magic and Natsu’s Fire Dragon Slayer Magic into her swords, effective against harming demons, dragons and other same name slayers.
Miku Hatsune (Fatal Frame) can use the Camera Obscura to combat ghosts.
David Xanatos (Gargoyles) created Steel Clan robots from cold iron to combat the Children of Oberon...
...as well as a cold iron exoframe.
Hellboy's (Hellboy) Good Samaritan is forged from a combination of Irish church bells, cold iron from crucifixes, blessed silver, and other mystic metals and utilizes bullets that contain white oak, holy water, garlic, silver shavings, and clove leaves, giving it the potential to injure many of the foes Hellboy may face.
Alexander Anderson (Hellsing) wields holy bayonets specifically to combat vampires.
Rudol von Stroheim (JoJo's Bizarre Adventure Part II: Battle Tendency) possesses a variety of ultraviolet weapons to combat vampires and the Pillar Men.
Keyblades (Kingdom Hearts) are incredibly effective weapons against the forces of darkness, such as Heartless.
Moebius' (Legacy of Kain) staff is a powerful anti-vampire weapon.
Link (The Legend of Zelda) wields the Master Sword; forged by Hylia and bathed in three Sacred Flames, it wields the power to slay demons and repel the forces of evil.
Stormbreaker (Marvel Cinematic Universe) is an Asgardian weapon forged specifically to harm and kill Thanos...
...which Thor used to grievously wound him.
Sentinels (Marvel Comics) possess a variety of weapons systems to counter and kill Mutants.
Blade (Marvel Comics) uses a variety of silver-coated steel weapons to hunt vampires.
The Spider Slayers (Marvel Comics) all possess different armaments for the purpose of capturing and/or killing Spider-Man.
Spider-Man (Marvel Comics) often uses different gadgets and weapons to counter certain individuals, with sonic weaponry to counter symbiotes...
...the Anti-Ock suit, meant specifically to counter Dr. Octopus...
...the Spider Armor MK III, powered armor meant specifically to counter all members of the Sinister Six...
...and an anti-magnetic inverter to disable the Vulture's wingsuit.
Norman Osborn/Green Goblin (Marvel Comics) has developed the Spider-Sense Gas to negate Spider-Man's powerful sixth sense and leave him vunerbale.
Alistaire Smythe (Marvel Comics) has developed all manner of weaponry to kill Spider-Man...
...such as a powerful Ethyl Chloride spray which greatly weakens the Wall Crawler.
Samus Aran's (Metroid) Ice Beam is a particularly deadly weapon against the cold-vulnerable Metroids.
Nenekirimaru (Nura: Rise of the Yokai Clan) is a spirit blade that only harms yokai, increasing in power with every yokai it cuts.
Aegis (Persona 3) is an Anti-Shadow Suppression Weapon, wielding a variety of weaponry to counter and destroy Shadows.
Bloodtox (Prototype) is a chemical weapon completely harmless to humans, but lethally toxic to those infected by the Blacklight virus.
Jack's (Samurai Jack) katana was specifically created for the purpose of harming and ultimately killing Aku.
Xeno Trunks (Super Dragon Ball Heroes) wields the Key Sword, a weapon created by gods to fight and seal demons.
Red X's (Teen Titans) suit and main weapon systems are specifically designed to combat and defeat all of the Teen Titans barring Robin.
Grune's (ThunderCats) Battle Club is forged with Thundrainium, an alloy deadly to Thunderians.
During the Spider-Verse event, Leopardon (Toei's Spider-Man) was outfitted with radiation-based weaponry specifically to combat the Inheritors.
Smoker (One Piece) wields a Seastone tipped Jitte which is highly useful when fighting Devil Fruit users.
Zephyr (One Piece) wields a massive Seastone mechanical arm the Battle Smasher to deal with Devil Fruit empowered opponents.
Quinques like Amon's Doujima (Tokyo Ghoul) are formed from the kagune of ghouls specifically to kill ghouls.
Rigel (Underworld) being burned alive by an ultraviolet bullet.
As a Witcher, Geralt of Rivia (The Witcher) wields a silver sword specifically to use on monsters.
Zero Kiryu (Vampire Knight) wielding the anti-vampire handgun Bloody Rose.
Yuki Kuran (Vampire Knight) wields the anti-vampire scythe Artemis.
The Ninja team (Lego Ninjago: Masters of Spinjitzu) had Aeroblades that were made from Deepstone to destroy ghost that came from the Cursed Realm.
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