Written by	David Byrne, Brian Eno, Chris Frantz, Jerry Harrison, Tina Weymouth
Date	1980
Source	Remain in Light (album)
Publisher	Index Music Inc., Bleu Disque Co. Inc., EG Music Ltd.

"Once in a Lifetime" is a Talking Heads song performed by Kermit the Frog in episode 109 of Muppets Tonight.

Kermit did the number to fill in for Giganticus, who was unable to make it for the show. The suit worn by Kermit in the number was made for Giganticus, which parodies the suit Talking Heads band member, David Byrne, wore on stage in the band's concert film Stop Making Sense.