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Missi Pyle (born 16 November 1972; age 52) is the actress who voiced the Interrogator in the Star Trek: Lower Decks second season episode "Strange Energies".

Pyle is known for playing the alien Laliari in Galaxy Quest (1999, starring Alan Rickman, featuring Rainn Wilson, Matt Winston, Robin Sachs, Heidi Swedberg, Wayne Péré, Larry Richards, Joel McKinnon Miller, Jack Nolan, Linda Harcharic, Susan McNabb, Spice Williams, and Tanner Gill).

She is also known for appearing in films such as Josie and the Pussycats (2001, with Hiro Kanagawa), Big Fish (2003, with Deep Roy and Hélène Cardona), Bringing Down the House (2003, with Randy Oglesby, Michael Ensign, and John Prosky), Along Came Polly (2004, with Todd Stashwick), Dodgeball: A True Underdog Story (2004, with William Shatner, Stephen Root, and Gary Cole), Charlie and the Chocolate Factory (2005, with Deep Roy), Harold & Kumar Escape from Guantanamo Bay (2008, starring John Cho), The Artist (2011, with James Cromwell, Ed Lauter, Malcolm McDowell, Andy Milder, Brian J. Williams, and Bill Blair), Gone Girl (2014, with Tyler Perry, David Clennon, Jamie McShane, Leonard Kelly-Young, and Bill Blair), Captain Fantastic (2016, with Frank Langella), and Ma (2019, with Dominic Burgess).

Pyle has also made a large number of television appearances. She is known for playing the recurring role of Jake's teacher, Delores Pasternak in Two and a Half Men (with Jeri Ryan, Liz Vassey, and Christian Slater). She also had a recurring role in three episodes of Boston Legal, starring William Shatner, René Auberjonois, and John Larroquette, with Michael Ensign, Ellen Bry, Henry Gibson, Larry Drake, Bruce Gray, and Leonard Kelly-Young. She also had a recurring role in Another Period (with Paul Scheer and Paul F. Tompkins).

In 2013-14, Pyle co-starred in Cleaners, with Clifton Collins, Jr. and John Savage in recurring roles. In 2014, she co-starred in Jennifer Falls, with Tom Virtue guesting in one episode. In 2021, she played the recurring role of Roxanne in Y: The Last Man, alongside Tara Nicodemo, Sophia Walker, Ayesha Mansur Gonsalves, Mimi Kuzyk, Avaah Blackwell, and Mercedes Blanche. In 2023, she co-starred in Harlan Coben's Shelter, featuring Sophia Adler.

She made guest appearances on a large number of series, including Friends, Ally McBeal (with Kevin Rahm and Renee E. Goldsberry), Roswell (with William Sadler and Richard McGonagle), Frasier (starring and directed by Kelsey Grammer, with Penny Johnson), My Name Is Earl (with Ellen Albertini Dow), Heroes (starring Santiago Cabrera, Greg Grunberg and Zachary Quinto, with Stan Lee, directed by Roxann Dawson), Pushing Daisies (created and written by Bryan Fuller), Numbers (with Christopher McDonald), Grey's Anatomy (with Gregg Henry), The Mentalist (with Antal Kalik and David Paymer), 2 Broke Girls (with Brian George), Warehouse 13 (starring Saul Rubinek, with Faran Tahir and Vanessa Smythe), The Mindy Project, Law & Order: Special Victims Unit (2015, starring Mariska Hargitay), and Major Crimes (starring Raymond Cruz and Jonathan Del Arco, with Wendy Davis).

She is also an accomplished voice actress who provided voices for series like Seth MacFarlane's American Dad! (with Wendy Schaal, Scott Grimes, Dee Bradley Baker, Amy Hill, Tzi Ma, and Kevin Michael Richardson) and Family Guy (with Kevin Michael Richardson), Bordertown (with Carlos Alazraqui and Seth MacFarlane), The Great North (with Kelvin Yu), and Archer (starring H. Jon Benjamin, with Gary Anthony Williams).

Pyle has also been active as a country singer. She was part of a group named Smith & Pyle with fellow actress Shawnee Smith, which released a digital album titled It's OK to Be Happy in 2008.

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