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SLC2A9

From Wikipedia, the free encyclopedia
SLC2A9
Identifiers
AliasesSLC2A9, solute carrier family 2 (facilitated glucose transporter), member 9, GLUT9, GLUTX, UAQTL2, URATv1, solute carrier family 2 member 9
External IDsOMIM: 606142; MGI: 2152844; HomoloGene: 69290; GeneCards: SLC2A9; OMA:SLC2A9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001290
NM_020041

NM_001012363
NM_001102414
NM_001102415
NM_145559

RefSeq (protein)

NP_001001290
NP_064425

NP_001012363
NP_001095884
NP_001095885
NP_663534

Location (UCSC)Chr 4: 9.77 – 10.05 MbChr 5: 38.51 – 38.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.[5][6][7]

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease.[8][9][10]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109667Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005107Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Phay JE, Hussain HB, Moley JF (Aug 2000). "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9)". Genomics. 66 (2): 217–20. doi:10.1006/geno.2000.6195. PMID 10860667.
  6. ^ Manolescu AR, Augustin R, Moley K, Cheeseman C (Aug 2007). "A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity". Mol Membr Biol. 24 (5–6): 455–63. doi:10.1080/09687680701298143. PMID 17710649. S2CID 35331716.
  7. ^ a b "SLC2A9 solute carrier family 2 member 9 [ Homo sapiens (human) ]".
  8. ^ Vitart V, Rudan I, Hayward C, et al. (2008). "SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout". Nature Genetics. 40 (4): 437–42. doi:10.1038/ng.106. PMID 18327257. S2CID 6720464.
  9. ^ Döring A, Gieger C, Mehta D, et al. (2008). "SLC2A9 influences uric acid concentrations with pronounced sex-specific effects". Nature Genetics. 40 (4): 430–6. doi:10.1038/ng.107. PMID 18327256. S2CID 29751482.
  10. ^ Hollingworth P, Sweet R, Sims R, et al. (2012). "Genome-wide association study of Alzheimer's disease with psychotic symptoms". Molecular Psychiatry. 17 (12): 1316–1327. doi:10.1038/mp.2011.125. PMC 3272435. PMID 22005930.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.