INHA

INHA
Identifiers
Aliases	INHA, inhibin alpha subunit, inhibin subunit alpha
External IDs	OMIM: 147380; MGI: 96569; HomoloGene: 1652; GeneCards: INHA; OMA:INHA - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,575,711 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,487,010 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right adrenal gland; ; left ovary; ; right adrenal cortex; ; left adrenal gland; ; right ovary; ; left adrenal cortex; ; gonad; ; right auricle;
	Top expressed in
	cumulus cell; ; Gonadal ridge; ; ovary; ; testicle; ; seminiferous tubule; ; superior frontal gyrus; ; spermatocyte; ; primary visual cortex; ; membrana granulosa of ovarian follicle; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; hormone activity; protein binding; protein heterodimerization activity; transforming growth factor beta receptor binding; growth factor activity; signaling receptor binding; inhibin binding;
Cellular component	cytoplasm; inhibin-betaglycan-ActRII complex; photoreceptor inner segment; photoreceptor outer segment; extracellular region; soma; inhibin A complex; inhibin B complex; extracellular space;
Biological process	regulation of apoptotic process; skeletal system development; cell differentiation; male gonad development; regulation of MAPK cascade; SMAD protein signal transduction; cell development; negative regulation of macrophage differentiation; cell-cell signaling; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of cell cycle; positive regulation of follicle-stimulating hormone secretion; regulation of cell cycle; cell surface receptor signaling pathway; regulation of cell population proliferation; hemoglobin biosynthetic process; negative regulation of B cell differentiation; ovarian follicle development; erythrocyte differentiation; negative regulation of follicle-stimulating hormone secretion; negative regulation of phosphorylation; signal transduction; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3623
	16322
	ENSG00000123999
	ENSMUSG00000032968
	P05111
	Q04997
	NM_002191
	NM_010564; NM_001329843
	NP_002182
	NP_001316772; NP_034694
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.^[5]

Function

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease.

However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123999 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032968 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
^ "Entrez Gene: INHA inhibin, alpha".

Mellor SL, Richards MG, Pedersen JS, Robertson DM, Risbridger GP (1998). "Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer". J. Clin. Endocrinol. Metab. 83 (3): 969–75. doi:10.1210/jcem.83.3.4640. PMID 9506758.
Munz B, Hübner G, Tretter Y, Alzheimer C, Werner S (1999). "A novel role of activin in inflammation and repair". J. Endocrinol. 161 (2): 187–93. doi:10.1677/joe.0.1610187. PMID 10320815.
Welt C, Sidis Y, Keutmann H, Schneyer A (2002). "Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium". Exp. Biol. Med. (Maywood). 227 (9): 724–52. doi:10.1177/153537020222700905. PMID 12324653. S2CID 19795772.
Shav-Tal Y, Zipori D (2003). "The role of activin a in regulation of hemopoiesis". Stem Cells. 20 (6): 493–500. doi:10.1634/stemcells.20-6-493. PMID 12456957. S2CID 36242096.
Shao L, Frigon NL, Young AL, Yu AL, Mathews LS, Vaughan J, et al. (1992). "Effect of activin A on globin gene expression in purified human erythroid progenitors". Blood. 79 (3): 773–81. doi:10.1182/blood.V79.3.773.bloodjournal793773. PMID 1310063.
Vannelli GB, Barni T, Forti G, Negro-Vilar A, Vale W, Serio M, et al. (1992). "Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study". Cell Tissue Res. 269 (2): 221–7. doi:10.1007/bf00319612. PMID 1423490.
Matzuk MM, Finegold MJ, Su JG, Hsueh AJ, Bradley A (1992). "Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice". Nature. 360 (6402): 313–9. Bibcode:1992Natur.360..313M. doi:10.1038/360313a0. PMID 1448148. S2CID 4327163.
Shimonaka M, Inouye S, Shimasaki S, Ling N (1991). "Follistatin binds to both activin and inhibin through the common subunit". Endocrinology. 128 (6): 3313–5. doi:10.1210/endo-128-6-3313. PMID 2036994.
Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). "Activin B: precursor sequences, genomic structure and in vitro activities". Mol. Endocrinol. 3 (9): 1352–8. doi:10.1210/mend-3-9-1352. PMID 2575216.
Barton DE, Yang-Feng TL, Mason AJ, Seeburg P, Francke U (1989). "Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice". Genomics. 5 (1): 91–9. doi:10.1016/0888-7543(89)90091-8. PMID 2767687.
Lappöhn RE, Burger HG, Bouma J, Bangah M, Krans M, De Bruijn HW (1989). "Inhibin as a marker for granulosa-cell tumors". N. Engl. J. Med. 321 (12): 790–3. doi:10.1056/NEJM198909213211204. PMID 2770810.
Mayo KE, Cerelli GM, Spiess J, Rivier J, Rosenfeld MG, Evans RM, et al. (1986). "Inhibin A-subunit cDNAs from porcine ovary and human placenta". Proc. Natl. Acad. Sci. U.S.A. 83 (16): 5849–53. Bibcode:1986PNAS...83.5849M. doi:10.1073/pnas.83.16.5849. PMC 386393. PMID 3016724.
Ramasharma K, Li CH (1987). "Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes". Proc. Natl. Acad. Sci. U.S.A. 84 (11): 3595–8. Bibcode:1987PNAS...84.3595R. doi:10.1073/pnas.84.11.3595. PMC 304921. PMID 3035540.
Murata M, Eto Y, Shibai H, Sakai M, Muramatsu M (1988). "Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain". Proc. Natl. Acad. Sci. U.S.A. 85 (8): 2434–8. Bibcode:1988PNAS...85.2434M. doi:10.1073/pnas.85.8.2434. PMC 280011. PMID 3267209.
Burger HG, Igarashi M (1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.
Mason AJ, Niall HD, Seeburg PH (1986). "Structure of two human ovarian inhibins". Biochem. Biophys. Res. Commun. 135 (3): 957–64. doi:10.1016/0006-291X(86)91021-1. PMID 3754442.
Stewart AG, Milborrow HM, Ring JM, Crowther C, Forage R (1986). "Human inhibin genes. Genomic characterisation and sequencing". FEBS Lett. 206 (2): 329–34. doi:10.1016/0014-5793(86)81006-7. PMID 3758355. S2CID 21261385.
Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995). "Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism". J. Biol. Chem. 270 (11): 6308–13. doi:10.1074/jbc.270.11.6308. PMID 7890768.
Nishihara T, Okahashi N, Ueda N (1994). "Activin A induces apoptotic cell death". Biochem. Biophys. Res. Commun. 197 (2): 985–91. doi:10.1006/bbrc.1993.2576. PMID 8267637.
Mason AJ, Farnworth PG, Sullivan J (1997). "Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A". Mol. Endocrinol. 10 (9): 1055–65. doi:10.1210/mend.10.9.8885240. PMID 8885240.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123999 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032968 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3345731-5] Burger HG, Igarashi M (April 1988). "Inhibin: definition and nomenclature, including related substances". Endocrinology. 122 (4): 1701–2. doi:10.1210/endo-122-4-1701. PMID 3345731.

[6] "Entrez Gene: INHA inhibin, alpha".

[1]

INHA

Function

See also

References

Further reading