In battle
Generation V
Moves used by a Pokémon with Infiltrator bypass the effects of targets' Reflect, Light Screen, Safeguard, and Mist.
Generation VI onward
Moves used by a Pokémon with Infiltrator also bypass the effects of targets' Aurora Veil.
Moves used by a Pokémon with Infiltrator, except Transform and Sky Drop, also bypass the effects of targets' substitutes.
Outside of battle
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This Ability effect may be in need of research. Reason: BDSP You can discuss this on the talk page.
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In Pokémon Sword and Shield, if a Pokémon with Infiltrator is in the first place in the party (even if fainted), the chance of generating a random encounter is decreased by 87.5%.