Scooby-Doo is an animated series produced for Saturday morning television in several different versions from 1969 to the present. The original series, Scooby-Doo, Where Are You!, was created for Hanna-Barbera Productions and has produced numerous spin-offs and related works until being absorbed in 2001 into Warner Bros. Animation. They have handled production since then. All versions of the show feature a talking dog named Scooby Doo; the original series included four teenagers or young adults: Fred "Freddie" Jones, Daphne Blake, Velma Dinkley, and Norville "Shaggy" Rogers. These five characters are officially and collectively known as "Mystery, Inc.".
In "I Never Met the Dead Man", Peter wonders what Scooby and the gang are up to on The Scooby Doo Murder Files, where Mystery Inc. gets to solve murders after he knocks out television in Quahog. Frank Welker reprised his role of Fred, whereas Lori Alan and Seth MacFarlane respectively voiced Velma and Scooby.
They also appear in "Family Guy Viewer Mail No. 1" segment "Lil' Griffins".
In "Deep Throats", Brian and Stewie walk to Mayor West’s office and find the Scooby Doo gang, with Stewie humming the famous “walking” music on Scooby Doo to get them to leave. Frank Welker again appeared in the voice role of Fred.
Scooby is mentioned in Family Guy: Live in Vegas.
To make Stewie feel better in "Stewie Loves Lois", Lois gives Stewie cut green beans, Atkins-friendly potato sticks, and a Scooby-Doo yogurt with Shaggy's eyes scratched out.
The team of Rush Limbaugh, John McCain, and Hot Dog solve mysteries in a similar manner. Hot Dog is a blatant parody of Scooby. They are seen in action in "Excellence in Broadcasting".
In It's A Trap!, R2-D2 runs away at the sight of the ghost of Obi-Wan Kenobi, played by Herbert, using Scooby Doo sound effects.
"Business Guy" parodies Scooby-Doo when Carter and Lois run from a swamp monster, using the music, sound effects, and style of the original chases from the 1969 series, in the end they unmask the monster after catching him in a net.
Peter references Scooby-Doo in "Grumpy Old Man" when he accuses a resident at the Oceanside Retirement Community of being "old man Withers who runs the haunted amusement park." When he tries to unmask him, he tears the old man's face off.
Chris answers Stewie with "Scooby-Doo" when quizzed on his history in "Stewie, Chris & Brian's Excellent Adventure".
Brian jokingly imitates Scooby-Doo at obedience school in "Once Bitten".
Stewie tells Brian that Rupert used to call him names in "Dog Bites Bear", including "Scooby-Don't."
When told he dumps lead in drinking water in "Regarding Carter", Carter expresses shock with "zoinks" in the same manner as Shaggy Rogers.
Dr. Hartman isn't sure if he heard about ghosts in med school or on Scooby-Doo in "Hefty Shades of Gray".
Peter compares himself and Brian to Scooby-Doo in "Connie's Celica" simply because he's a guy with a dog trying to solve a crime.
In "The Lois Quagmire", Lois claims that Peter believes that Scrappy-Doo is superior to Scooby-Doo.
In "First Blood", Peter compares Wild West's bear disguise to a Scooby-Doo plot, leading Joe to note that the villains are often small businessmen.