Mrs. Wilson is a teacher at Martin Mull Elementary School.
She was Peter Griffin's third grade teacher when he was a child. Griffin and his friends called her "Mrs. Kill-son" because she had an abortion. When Griffin needs to pass the third grade in order to get a promotion in "Tales of a Third Grade Nothing", she becomes his teacher once again. One of her other students is Glenn Quagmire's illegitimate children. She passes Peter after he wins a spelling bee for his school, facing Omar, another child in her class.
Mrs. Wilson is voiced by Debbie Reynolds.
Despite not having actually dying on the show, she is seen in a hallucination of Peter's on a cruise ship full of deceased characters in the Panama Canal in "Coma Guy".