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File:Steroidogenesis.svg

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Summary

Description
English: *Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

  • White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula.
  • Arrows are shown as unidirectional to indicate the usual net directions, but technically all biochemical reactions are considered bidirectional.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.

See also:

Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は（コレステロールから）プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。

図に示すとおりそれぞれ（生合成の過程で）オーバーラップするものである。 図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。

なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
Date
Source Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author

David Richfield (Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

In external use, this diagram may be cited as:

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Original. See also Evolution.
Raster (.png) version is available

Translations

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    中文
  • 國語
    國語
  • Русский
    Русский
  • Galego
    Galego
  • العربية
    العربية
  • polski
    polski
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  • 日本語
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SVG development
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The chemistry symbols of this structural formula are drawn using the path text method.

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Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.

Licensing

Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

Captions

A schematic diagram showing the chemicals, enzymes, and locations of the human steroidogenesis pathways.

Items portrayed in this file

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inception

28 March 2009

media type

image/svg+xml

checksum

589c3a5c90f5b91cbf4801dfd14cb2b515a1ce31

determination method or standard: SHA-1

data size

256,760 byte

height

1,105 pixel

width

1,245 pixel

File history

Click on a date/time to view the file as it appeared at that time.

(newest | oldest) View (newer 10 | ) (10 | 20 | 50 | 100 | 250 | 500)
Date/TimeThumbnailDimensionsUserComment
current09:21, 8 May 2024Thumbnail for version as of 09:21, 8 May 20241,245 × 1,105 (251 KB)Bjankuloski06File uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for mk.
10:52, 28 October 2022Thumbnail for version as of 10:52, 28 October 20221,245 × 1,105 (224 KB)Uxue GarcíaFile uploaded using svgtranslate tool (https://svgtranslate.toolforge.org/). Added translation for eu.
15:58, 8 April 2020Thumbnail for version as of 15:58, 8 April 20201,245 × 1,105 (198 KB)АтаFile uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
15:54, 8 April 2020Thumbnail for version as of 15:54, 8 April 20201,245 × 1,105 (187 KB)АтаFile uploaded using svgtranslate tool (https://tools.wmflabs.org/svgtranslate/). Added translation for uk.
15:12, 13 March 2013Thumbnail for version as of 15:12, 13 March 20131,245 × 1,105 (133 KB)SlashmeRemoved arrow from Corticosterone to Cortisol via CYP17A1 (see http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
16:15, 9 July 2012Thumbnail for version as of 16:15, 9 July 20121,245 × 1,105 (133 KB)Mikael HäggströmAddition and correction of stereochemistries at positions 11 and 17.
04:24, 9 July 2012Thumbnail for version as of 04:24, 9 July 20121,245 × 1,105 (127 KB)Mikael HäggströmAdded stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
05:15, 13 December 2011Thumbnail for version as of 05:15, 13 December 20111,245 × 1,105 (114 KB)SlashmeAlign some text and arrows for neatness' sake.
04:56, 13 December 2011Thumbnail for version as of 04:56, 13 December 20111,245 × 1,105 (114 KB)SlashmeFixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
12:58, 8 May 2010Thumbnail for version as of 12:58, 8 May 20101,245 × 1,105 (114 KB)Mikael Häggströmminor move of 5-a-reductase
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