L-741,626: Difference between revisions
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Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'DrugBank_Ref', 'ChEBI_Ref') per [[WP:CHEMVALID|Chem/Dr |
removed Category:Chloroarenes; added Category:4-Chlorophenyl compounds using HotCat |
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{{Short description|Chemical compound}} |
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{{Drugbox |
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| pregnancy_category = |
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| legal_status = |
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| routes_of_administration = |
| routes_of_administration = |
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<!--Pharmacokinetic data--> |
<!--Pharmacokinetic data--> |
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| metabolism = |
| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
<!--Identifiers--> |
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| IUPHAR_ligand = 177 |
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| CAS_number_Ref = {{cascite|correct|CAS}} |
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| CAS_number = 81226-60-0 |
| CAS_number = 81226-60-0 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = WTW4A6SW92 |
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| ATC_prefix = none |
| ATC_prefix = none |
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| ATC_suffix = |
| ATC_suffix = |
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| PubChem = 133633 |
| PubChem = 133633 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 117877 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=20 | H=21 | Cl=1 | N=2 | O=1 |
| C=20 | H=21 | Cl=1 | N=2 | O=1 |
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| molecular_weight = 340.134 g/mol |
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| smiles = OC(CC1)(C2=CC=C(Cl)C=C2)CCN1CC3=CNC4=CC=CC=C43 |
| smiles = OC(CC1)(C2=CC=C(Cl)C=C2)CCN1CC3=CNC4=CC=CC=C43 |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2 |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = LLBLNMUONVVVPG-UHFFFAOYSA-N |
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'''L-741,626''' is a drug which acts as a potent and selective [[Antagonist (pharmacology)|antagonist]] for the [[dopamine]] [[Receptor (biochemistry)|receptor]] [[Dopamine receptor D2|D<sub>2</sub>]]. It has good selectivity over the related [[Dopamine receptor D3|D<sub>3</sub>]] and [[Dopamine receptor D4|D<sub>4</sub>]] subtypes and other receptors. L-741,626 is used for laboratory research into brain function and has proved particularly useful for distinguishing D<sub>2</sub> mediated responses from those produced by the closely related D<sub>3</sub> subtype, and for studying the roles of these subtypes in the action of [[cocaine]] and [[amphetamine]]s in the brain.<ref name="pmid8968560">{{cite journal | |
'''L-741,626''' is a drug which acts as a potent and selective [[Antagonist (pharmacology)|antagonist]] for the [[dopamine]] [[Receptor (biochemistry)|receptor]] [[Dopamine receptor D2|D<sub>2</sub>]]. It has good selectivity over the related [[Dopamine receptor D3|D<sub>3</sub>]] and [[Dopamine receptor D4|D<sub>4</sub>]] subtypes and other receptors. L-741,626 is used for laboratory research into brain function and has proved particularly useful for distinguishing D<sub>2</sub> mediated responses from those produced by the closely related D<sub>3</sub> subtype, and for studying the roles of these subtypes in the action of [[cocaine]] and [[amphetamine]]s in the brain.<ref name="pmid8968560">{{cite journal |=Bowery BJ, Razzaque Z, Emms F, Patel S, Freedman S, Bristow L, Kulagowski J, Seabrook GR |title=Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626 |journal=British Journal of Pharmacology |volume=119 |issue=7 |pages=1491–7 |=1996 |pmid=8968560 |pmc=1915834 |doi= }}</ref><ref name="pmid11113496">{{cite journal |=Canales JJ, Iversen SD |title=Psychomotor-activating effects mediated by dopamine D(2) and D(3) receptors in the nucleus accumbens |journal=Pharmacology Biochemistry and Behavior |volume=67 |issue=1 |pages=161–8 |=2000 |pmid=11113496 |doi= 10.1016/S0091-3057(00)00311-7|=}}</ref><ref name="pmid11702088">{{cite journal |=Costanza RM, Barber DJ, Terry P |title=Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists |journal=Psychopharmacology |volume=158 |issue=2 |pages=146–53 |=2001 |pmid=11702088 |doi=10.1007/s002130100872 |=}}</ref><ref name="pmid12763098">{{cite journal |=Chaperon F, Tricklebank MD, Unger L, Neijt HC |title=Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors |journal=Neuropharmacology |volume=44 |issue=8 |pages=1047–53 |=2003 |pmid=12763098 |doi= 10.1016/S0028-3908(03)00113-8|=}}</ref><ref name="pmid17095222">{{cite journal |=Grundt P, Husband SL, Luedtke RR, Taylor M, Newman AH |title=Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR |journal=Bioorganic & Medicinal Chemistry Letters |volume=17 |issue=3 |pages=745–9 |=2007 |pmid=17095222 |pmc=1851912 |doi=10.1016/j.bmcl.2006.10.076 }}</ref><ref name="pmid18807248">{{cite journal |=Koffarnus MN, Greedy B, Husbands SM, Grundt P, Newman AH, Woods JH |title=The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats |journal=Psychopharmacology |volume=203 |issue=2 |pages=317–27 |=2009 |pmid=18807248 |pmc=3065021 |doi=10.1007/s00213-008-1323-4 }}</ref><ref name="pmid19584712">{{cite journal |=Depoortère R, Bardin L, Rodrigues M, Abrial E, Aliaga M, Newman-Tancredi A |title=Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors |journal=Behavioural Pharmacology |volume=20 |issue=4 |pages=303–11 |=2009 |pmid=19584712 |doi=10.1097/FBP.0b013e32832ec5aa |=}}</ref><ref name="pmid19840852">{{cite journal |=Fan X, Xu M, Hess EJ |title=D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD |journal=Neurobiology of Disease |volume=37 |issue=1 |pages=228–36 |=2010 |pmid=19840852 |pmc=2839459 |doi=10.1016/j.nbd.2009.10.009 }}</ref><ref name="pmid20494958">{{cite journal |=Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD |title=Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys |journal=The Journal of Pharmacology and Experimental Therapeutics |volume=334 |issue=2 |pages=556–65 |=2010 |pmid=20494958 |doi=10.1124/jpet.110.167619 |=}}</ref><ref name="pmid21414250">{{cite journal |=Watson DJ, Marsden CA, Millan MJ, Fone KC |title=Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment |journal=The International Journal of Neuropsychopharmacology |volume= |issue= |pages= |=2011 |pmid=21414250 |doi=10.1017/S1461145711000435 |=}}</ref> |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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{{Dopaminergics}} |
{{Dopaminergics}} |
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[[Category: |
[[Category: antagonists]] |
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[[Category:Indoles]] |
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[[Category:4-Phenylpiperidines]] |
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[[Category:Tertiary alcohols]] |
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[[Category:4-Chlorophenyl compounds]] |
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