DCPG: Difference between revisions

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{{Drugbox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = ~~427406643~~

| verifiedrevid =

| IUPAC_name = 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid

| image = DCPG_structure.png

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| legal_US =

| legal_status =

| routes_of_administration =

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| metabolism =

| elimination_half-life =

| excretion =

| CAS_number_Ref = {{cascite|correct|CAS}}

| CAS_number = 201730-11-2

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = W3Y53JA9W3

| ATC_prefix =

| ATC_suffix =

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| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank =

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 17222214

⚫

| smiles = =O)C(N)C(O)O)(=O)O

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = IJVMOGKBEVRBPP-ZETCQYMHSA-N

| C=10 | H=9 | N=1 | O=6

| molecular_weight = 239.181 g/mol

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| smiles = ~~OC(~~=O)~~c1cc(~~C(N)C(O)=O)~~ccc1C~~(=O)O

}}

'''DCPG''' ('''(S)-3,4-DCPG''') is a drug used in scientific research, which acts as a potent and subtype-selective [[agonist]] for the [[metabotropic glutamate receptor]] [[Metabotropic glutamate receptor 8|mGluR<sub>8</sub>]]. It has [[anticonvulsant]] effects in animal studies,<ref>Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. ''European Journal of Pharmacology~~''.~~ ~~2003~~ ~~Aug~~ ~~22;~~476~~(1-2):3-16.~~ ~~{{DOI~~|10.1016/~~S0014~~-2999(03)02149-6}} ~~PMID 12969743~~</ref><ref>Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. ''Neuropharmacology~~''.~~ ~~2008~~ ~~Mar;~~54(4~~):665-75.~~ ~~PMID~~ 18191956</ref> and has also been investigated as a possible treatment for [[hyperalgesia]].<ref>Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ''Neuropharmacology~~''.~~ ~~2007~~ ~~Feb;~~52(2~~):253-62.~~ ~~PMID~~ 17113112</ref>

'''DCPG''' ('''(S)-3,4-DCPG''') is a drug used in scientific research, which acts as a potent and subtype-selective [[agonist]] for the [[metabotropic glutamate receptor]] [[Metabotropic glutamate receptor 8|mGluR<sub>8</sub>]]. It has [[anticonvulsant]] effects in animal studies,<ref>Moldrich RX, Chapman AG, De Sarro G, Meldrum BS Glutamate metabotropic receptors as targets for drug therapy in epilepsy European Journal of Pharmacology 476 |10.1016/-2999(03)02149-6}}</ref><ref>Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid Neuropharmacology 544 18191956</ref> and has also been investigated as a possible treatment for [[hyperalgesia]].<ref>Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice Neuropharmacology 522 17113112</ref>

== References ==

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[[Category:Alpha-Amino acids]]

[[Category:Anticonvulsants]]

[[Category:Amino acid derivatives]]

[[Category:Tricarboxylic acids]]

[[Category:MGlu8 receptor agonists]]