Phorate

Phorate
Names
	Preferred IUPAC name O,O-Diethyl S-[(ethylsulfanyl)methyl] phosphorodithioate
	Other names Thimet (trademark); 3911 (trademark)
Identifiers
CAS Number	298-02-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:38764 ;
ChEMBL	ChEMBL510014 ;
ChemSpider	4626 ;
ECHA InfoCard	100.005.503
PubChem CID	4790;
UNII	3W54X3W9IV ;
CompTox Dashboard (EPA)	DTXSID4032459 ;
	InChI InChI=1S/C7H17O2PS3/c1-4-8-10(11,9-5-2)13-7-12-6-3/h4-7H2,1-3H3 Key: BULVZWIRKLYCBC-UHFFFAOYSA-N ; InChI=1/C7H17O2PS3/c1-4-8-10(11,9-5-2)13-7-12-6-3/h4-7H2,1-3H3 Key: BULVZWIRKLYCBC-UHFFFAOYAA;
	SMILES S=P(OCC)(SCSCC)OCC;
Properties
Chemical formula	C7H17O2PS3
Molar mass	260.36 g·mol−1
Appearance	Colorless liquid
Odor	Skunk-like
Density	1.16 g/mL
Melting point	−43 °C; −45 °F; 230 K
Boiling point	118-120°C (2.0 mm Hg)
Solubility in water	0.005% (20°C)
Vapor pressure	0.0008 mmHg (20°C)
Hazards
Flash point	160 °C; 320 °F; 433 K (open cup)
	NIOSH (US health exposure limits):
PEL (Permissible)	none
REL (Recommended)	TWA 0.05 mg/m3 ST 0.2 mg/m3 [skin]
IDLH (Immediate danger)	N.D.
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Phorate is an organophosphate used as an insecticide and acaricide.

Overview

At normal conditions, it is a pale yellow mobile liquid poorly soluble in water but readily soluble in organic solvents. It is relatively stable and hydrolyses only at very acidic or basic conditions. It is very toxic both for target organisms and for mammals including humans. It inhibits acetylcholinesterase and butyrylcholinesterase.^[3]

Phorate is most commonly applied in granular form. It is non-biocumulative and has no residual action. But some metabolites may persist in soil. It also damages some seeds.^[3]

Toxicity

Phorate (Thimate) is absorbed readily through all ways. Its toxicity is high. Oral LD₅₀ to rats is 1.1 – 3.2 mg/kg, to mice 3.5 – 6.5 mg/kg (technical phorate). Similar values has been found out to birds.^[3]

References

^ ^a ^b ^c ^d ^e ^f ^g ^h NIOSH Pocket Guide to Chemical Hazards. "#0502". National Institute for Occupational Safety and Health (NIOSH).
^ Farm Chemicals Handbook, Meister Publishing Co., Willoughby, OH (1991)
^ ^a ^b ^c "Data sheets on pesticides No. 75 – Phorate". Archived from the original on 2014-07-02. Retrieved 2011-07-31.

External links

Phorate in the Pesticide Properties DataBase (PPDB)

[PGCH-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h NIOSH Pocket Guide to Chemical Hazards. "#0502". National Institute for Occupational Safety and Health (NIOSH).

[2] Farm Chemicals Handbook, Meister Publishing Co., Willoughby, OH (1991)

[pds-3] "Data sheets on pesticides No. 75 – Phorate". Archived from the original on 2014-07-02. Retrieved 2011-07-31.

[1]

Names

Preferred IUPAC name O,O-Diethyl S-[(ethylsulfanyl)methyl] phosphorodithioate
Other names Thimet (trademark) 3911 (trademark)
Identifiers
CAS Number	298-02-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:38764^N
ChEMBL	ChEMBL510014^N
ChemSpider	4626^Y
ECHA InfoCard	100.005.503
PubChem CID	4790
UNII	3W54X3W9IV^Y
CompTox Dashboard (EPA)	DTXSID4032459
InChI InChI=1S/C7H17O2PS3/c1-4-8-10(11,9-5-2)13-7-12-6-3/h4-7H2,1-3H3^Y Key: BULVZWIRKLYCBC-UHFFFAOYSA-N^Y InChI=1/C7H17O2PS3/c1-4-8-10(11,9-5-2)13-7-12-6-3/h4-7H2,1-3H3 Key: BULVZWIRKLYCBC-UHFFFAOYAA
SMILES S=P(OCC)(SCSCC)OCC
Properties
Chemical formula	C₇H₁₇O₂PS₃
Molar mass	260.36 g·mol⁻¹
Appearance	Colorless liquid
Odor	Skunk-like^[1]
Density	1.16 g/mL
Melting point	−43 °C; −45 °F; 230 K^[1]
Boiling point	118-120°C (2.0 mm Hg)^[2]
Solubility in water	0.005% (20°C)^[1]
Vapor pressure	0.0008 mmHg (20°C)^[1]
Hazards
Flash point	160 °C; 320 °F; 433 K (open cup)^[1]
NIOSH (US health exposure limits):
PEL (Permissible)	none^[1]
REL (Recommended)	TWA 0.05 mg/m³ ST 0.2 mg/m³ [skin]^[1]
IDLH (Immediate danger)	N.D.^[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references