VCAM1

VCAM1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IJ9, 1VCA, 1VSC
Dynodwyr
Cyfenwau	VCAM1, CD106, INCAM-100, vascular cell adhesion molecule 1
Dynodwyr allanol	OMIM: 192225 HomoloGene: 838 GeneCards: VCAM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • primary amine oxidase activity • integrin binding • cell adhesion molecule binding Cydrannau o'r gell • integral component of membrane • Golgi apparatus • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex • bilen • filopodium • Cellbilen • apical part of cell • microvillus • cell surface • early endosome • Reticwlwm endoplasmig • podosome • sarcolemma • extracellular exosome • external side of plasma membrane • extracellular space • integral component of plasma membrane Prosesau biolegol • leukocyte cell-cell adhesion • response to ionizing radiation • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • response to hypoxia • response to nutrient • interferon-gamma-mediated signaling pathway • cellular response to tumor necrosis factor • response to nicotine • GO:0010260 heneiddio • response to zinc ion • extracellular matrix organization • amine metabolic process • response to lipopolysaccharide • cell adhesion • acute inflammatory response • positive regulation of T cell proliferation • membrane to membrane docking • regulation of immune response • leukocyte tethering or rolling • cell chemotaxis • B cell differentiation • cellular response to vascular endothelial growth factor stimulus • cell-matrix adhesion • GO:0022415 viral process • response to ethanol • calcium-mediated signaling using intracellular calcium source • chronic inflammatory response • cell-cell adhesion • cytokine-mediated signaling pathway • heterotypic cell-cell adhesion • innervation • cardiac neuron differentiation • cell-cell adhesion in response to extracellular stimulus • cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7412	n/a
Ensembl	ENSG00000162692	n/a
UniProt	P19320	n/a
RefSeq (mRNA)	NM_080682 NM_001078 NM_001199834	n/a
RefSeq (protein)	NP_001069 NP_001186763 NP_542413	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VCAM1 yw VCAM1 a elwir hefyd yn Vascular cell adhesion molecule 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p21.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VCAM1.

• CD106
• INCAM-100

• "Mesothelium expression of vascular cell adhesion molecule-1 (VCAM-1) is associated with an unfavorable prognosis in epithelial ovarian cancer (EOC). ". Cancer. 2017. PMID 28263384.
• "Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers. ". Inflamm Res. 2017. PMID 27853845.
• "Correlation of VCAM-1 expression in serum, cord blood, and placental tissue with gestational hypertension associated with fetal growth restriction in women from Xingtai Hebei, China. ". Genet Mol Res. 2016. PMID 27706617.
• "Increased circulating VCAM-1 correlates with advanced disease and poor survival in patients with multiple myeloma: reduction by post-bortezomib and lenalidomide treatment. ". Blood Cancer J. 2016. PMID 27232930.
• "Glycated LDL increase VCAM-1 expression and secretion in endothelial cells and promote monocyte adhesion through mechanisms involving endoplasmic reticulum stress.". Mol Cell Biochem. 2016. PMID 27206739.