KEAP1

KEAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1U6D, 1ZGK, 2FLU, 3VNG, 3VNH, 3ZGC, 3ZGD, 4CXI, 4CXJ, 4CXT, 4IFJ, 4IFL, 4IFN, 4IN4, 4IQK, 4L7B, 4L7C, 4L7D, 4N1B, 4XMB
Dynodwyr
Cyfenwau	KEAP1, INrf2, KLHL19, kelch like ECH associated protein 1
Dynodwyr allanol	OMIM: 606016 HomoloGene: 8184 GeneCards: KEAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transcription factor binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • protein homodimerization activity • disordered domain specific binding • identical protein binding Cydrannau o'r gell • cytoplasm • Cul3-RING ubiquitin ligase complex • nucleoplasm • microtubule organizing center • midbody • Reticwlwm endoplasmig • Microffilament • cnewyllyn cell • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • cellular response to interleukin-4 • regulation of epidermal cell differentiation • GO:0009373 regulation of transcription, DNA-templated • in utero embryonic development • proteasomal ubiquitin-independent protein catabolic process • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • protein ubiquitination • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • cytoplasmic sequestering of transcription factor • protein deubiquitination • post-translational protein modification • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9817	n/a
Ensembl	ENSG00000079999	n/a
UniProt	Q14145	n/a
RefSeq (mRNA)	NM_012289 NM_203500	n/a
RefSeq (protein)	NP_036421 NP_987096	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KEAP1 yw KEAP1 a elwir hefyd yn Kelch like ECH associated protein 1 a Kelch-like ECH-associated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KEAP1.

• INrf2
• KLHL19

• "Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. ". Proc Natl Acad Sci U S A. 2015. PMID 26195781.
• "Keap1 expression has independent prognostic value in pancreatic adenocarcinomas. ". Diagn Pathol. 2015. PMID 25879528.
• "Keap1 as the redox sensor of the antioxidant response. ". Arch Biochem Biophys. 2017. PMID 27769838.
• "Expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 in breast cancer. ". Genet Mol Res. 2016. PMID 27323010.
• "Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region.". Oncotarget. 2016. PMID 27029077.