VPS4B

VPS4B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WR0, 1XWI, 2CPT, 2JQH, 2JQK, 4U7Y
Dynodwyr
Cyfenwau	VPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
Dynodwyr allanol	OMIM: 609983 HomoloGene: 37976 GeneCards: VPS4B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein homodimerization activity • ATPase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • hydrolase activity • ATP binding Cydrannau o'r gell • cytoplasm • cytosol • endosome • centrosome • spindle pole • bilen • late endosome membrane • Flemming body • endosome membrane • extracellular exosome • cnewyllyn cell Prosesau biolegol • late endosomal microautophagy • regulation of centrosome duplication • protein depolymerization • viral budding via host ESCRT complex • GO:0019067 viral life cycle • nucleus organization • cholesterol transport • negative regulation of exosomal secretion • multivesicular body assembly • negative regulation of cell death • regulation of mitotic spindle assembly • endosome organization • Cellraniad • positive regulation of centriole elongation • endosomal transport • potassium ion transport • response to lipid • ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway • protein transport • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • positive regulation of G2/M transition of mitotic cell cycle • positive regulation of exosomal secretion • septum digestion after cytokinesis • mitotic metaphase plate congression • endosome to lysosome transport via multivesicular body sorting pathway • cell cycle • ESCRT III complex disassembly • macroautophagy • GO:0015915 transport • positive regulation of viral process • vacuole organization • midbody abscission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9525	n/a
Ensembl	ENSG00000119541	n/a
UniProt	O75351	n/a
RefSeq (mRNA)	NM_004869	n/a
RefSeq (protein)	NP_004860 NP_004860.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VPS4B yw VPS4B a elwir hefyd yn Vacuolar protein sorting 4B (Yeast), isoform CRA_a a Vacuolar protein sorting 4 homolog B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VPS4B.

• "Inhibition of HBV replication by VPS4B and its dominant negative mutant VPS4B-K180Q in vivo. ". J Huazhong Univ Sci Technolog Med Sci. 2012. PMID 22684550.
• "Structural characterization of the MIT domain from human Vps4b. ". Biochem Biophys Res Commun. 2005. PMID 16018968.
• "Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells. ". Int J Hematol. 2015. PMID 25804841.
• "Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease. ". Exp Mol Pathol. 2015. PMID 25533544.
• "Vacuolar protein sorting 4B, an ATPase protein positively regulates the progression of NSCLC via promoting cell division.". Mol Cell Biochem. 2013. PMID 23737133.