METAP2

METAP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B59, 1B6A, 1BN5, 1BOA, 1KQ0, 1KQ9, 1QZY, 1R58, 1R5G, 1R5H, 1YW7, 1YW8, 1YW9, 2ADU, 2EA2, 2EA4, 2GA2, 2OAZ, 5CLS, 5D6E, 5D6F, 5JFR, 5JHU, 5JI6
Dynodwyr
Cyfenwau	METAP2, MAP2, MNPEP, p67, p67eIF2, methionyl aminopeptidase 2
Dynodwyr allanol	OMIM: 601870 HomoloGene: 4981 GeneCards: METAP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • metalloexopeptidase activity • hydrolase activity • metal ion binding • aminopeptidase activity • RNA binding • metalloaminopeptidase activity Cydrannau o'r gell • cytoplasm • Cellbilen • cytosol Prosesau biolegol • peptidyl-methionine modification • protein processing • N-terminal protein amino acid modification • proteolysis • regulation of rhodopsin mediated signaling pathway • protein initiator methionine removal Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10988	n/a
Ensembl	ENSG00000111142	n/a
UniProt	P50579	n/a
RefSeq (mRNA)	NM_006838 NM_001317182 NM_001317183 NM_001330246	n/a
RefSeq (protein)	NP_001304111 NP_001304112 NP_001317175 NP_006829	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn METAP2 yw METAP2 a elwir hefyd yn Methionine aminopeptidase 2 a Methionyl aminopeptidase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q22.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn METAP2.

• MAP2
• MNPEP
• p67eIF2

• "Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. ". Biochem Biophys Res Commun. 2013. PMID 24041691.
• "Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. ". Bioorg Med Chem Lett. 2006. PMID 16632353.
• "Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers. ". Adv Clin Exp Med. 2016. PMID 26935506.
• "Redox regulation of methionine aminopeptidase 2 activity. ". J Biol Chem. 2014. PMID 24700462.
• "Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity.". Diabetes Metab Syndr Obes. 2014. PMID 24611021.