File:3dp-humanbone.png
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3dp-humanbone.png (702 × 395 pixels, file size: 252 KB, MIME type: image/png)
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English: Bone tissue engineering has developed significantly in recent years as the increasing demand for bone substitutes due to trauma, cancer, arthritis, and infections. The scaffolds for bone regeneration need to be mechanically stable and have a 3D architecture with interconnected pores. With the advances in additive manufacturing technology, these requirements can be fulfilled by 3D printing scaffolds with controlled geometry and porosity using a low-cost multistep process. The scaffolds, however, must also be bioactive to promote the environment for the cells to regenerate into bone tissue. To determine if a low-cost 3D printing method for bespoke SiOC(N) porous structures can regenerate bone these structures were tested for osteointegration potential by using human mesenchymal stem cells (hMSCs). This includes checking the general biocompatibilities under the osteogenic differentiation environment (cell proliferation and metabolism). Moreover, cell morphology was observed by confocal microscopy and gene expressions on typical osteogenic markers at different stages for bone formation were determined by real-time PCR. The results of the study showed the pore size of the scaffolds had a significant impact on differentiation. A certain range of pore size could stimulate osteogenic differentiation, thus promoting bone regrowth and regeneration.
Yuejiao Yang, Apoorv Kulkarni, Gian Domenico Soraru, Joshua M Pearce, Antonella Motta. 3D printed SiOC(N) ceramic scaffolds for bone tissue regeneration: improved osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells. International Journal of Molecular Sciences 2021, 22(24), 13676; https://doi.org/10.3390/ijms222413676 OA, academia |
Date | |
Source | https://www.appropedia.org/3D_Printed_SiOC(N)_Ceramic_Scaffolds_for_Bone_Tissue_Regeneration:_Improved_Osteogenic_Differentiation_of_Human_Bone_Marrow‐Derived_Mesenchymal_Stem_Cells |
Author | Joshua M. Pearce |
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current | 20:05, 18 November 2023 | 702 × 395 (252 KB) | Yew know (talk | contribs) | Uploaded a work by Joshua M. Pearce from https://www.appropedia.org/3D_Printed_SiOC(N)_Ceramic_Scaffolds_for_Bone_Tissue_Regeneration:_Improved_Osteogenic_Differentiation_of_Human_Bone_Marrow‐Derived_Mesenchymal_Stem_Cells with UploadWizard |
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Categories:
- 3D printing
- Polymer derived ceramics
- Osteogenic differentiation
- Human mesenchymal stem cells
- Fused filament fabrication
- Cell anatomy
- Scaffolding
- Bone regeneration
- Material extrusion
- Open source
- Additive Manufacturing
- Open hardware
- RepRap
- Polysilazanes
- Preceramic polymers
- Thermoplastic polyurethanes
- Sustainable Development Goal 9
- Sustainable Development Goal 10
- Sustainable Development Goal 12
- Sustainable Development Goal 3
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