ADGRL2

ADGRL2
Identifikatori
Aliasi	ADGRL2
Vanjski ID-jevi	OMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	81,993,932 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	148,990,555 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• G protein-coupled receptor activity; • transmembrane signaling receptor activity; • latrotoxin receptor activity; • signal transducer activity; • carbohydrate binding;
Ćelijska komponenta	• integral component of membrane; • membrana; • intracellular anatomical structure; • integral component of plasma membrane; • neuron projection;
Biološki proces	• G protein-coupled receptor signaling pathway; • cell surface receptor signaling pathway; • GO:0072468 Transdukcija signala; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • brain development;
	Izvori:Amigo / QuickGO
Ortolozi
	23266
	99633
	ENSG00000117114
	ENSMUSG00000028184
	O95490
	Q8JZZ7
NM_001297704; NM_001297705; NM_001297706; NM_012302; NM_001330645;
	NM_001350698; NM_001350699; NM_001366002; NM_001366003; NM_001366004; NM_001366005; NM_001366006; NM_001366007; NM_001366008; NM_001366009; NM_001393349; NM_001393350; NM_001393351; NM_001393352; NM_001393353; NM_001393354
	NM_001081298
NP_001284633; NP_001284634; NP_001284635; NP_001317574; NP_036434;
	NP_001337627; NP_001337628; NP_001352931; NP_001352932; NP_001352933; NP_001352934; NP_001352935; NP_001352936; NP_001352937; NP_001352938
NP_001074767; NP_001392915; NP_001392916; NP_001392917; NP_001392918;
	NP_001392919; NP_001392920; NP_001392921; NP_001392922; NP_001392923; NP_001392924; NP_001392925; NP_001392926; NP_001392927; NP_001392928; NP_001392929; NP_001392930; NP_001392931; NP_001392932; NP_001392933; NP_001392934; NP_001392935; NP_001392936; NP_001392937; NP_001392938; NP_001392939; NP_001392940; NP_001392947; NP_001392948
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Latrofilin 2 jest protein koji je kod ljudi kodiran genom ADGRL2 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.459 aminokiselina, a molekulska težina 163.349 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVSSGCRMRS	LWFIIVISFL	PNTEGFSRAA	LPFGLVRREL	SCEGYSIDLR
CPGSDVIMIE	SANYGRTDDK	ICDADPFQME	NTDCYLPDAF	KIMTQRCNNR
TQCIVVTGSD	VFPDPCPGTY	KYLEVQYECV	PYIFVCPGTL	KAIVDSPCIY
EAEQKAGAWC	KDPLQAADKI	YFMPWTPYRT	DTLIEYASLE	DFQNSRQTTT
YKLPNRVDGT	GFVVYDGAVF	FNKERTRNIV	KFDLRTRIKS	GEAIINYANY
HDTSPYRWGG	KTDIDLAVDE	NGLWVIYATE	QNNGMIVISQ	LNPYTLRFEA
TWETVYDKRA	ASNAFMICGV	LYVVRSVYQD	NESETGKNSI	DYIYNTRLNR
GEYVDVPFPN	QYQYIAAVDY	NPRDNQLYVW	NNNFILRYSL	EFGPPDPAQV
PTTAVTITSS	AELFKTIIST	TSTTSQKGPM	STTVAGSQEG	SKGTKPPPAV
STTKIPPITN	IFPLPERFCE	ALDSKGIKWP	QTQRGMMVER	PCPKGTRGTA
SYLCMISTGT	WNPKGPDLSN	CTSHWVNQLA	QKIRSGENAA	SLANELAKHT
KGPVFAGDVS	SSVRLMEQLV	DILDAQLQEL	KPSEKDSAGR	SYNKLQKREK
TCRAYLKAIV	DTVDNLLRPE	ALESWKHMNS	SEQAHTATML	LDTLEEGAFV
LADNLLEPTR	VSMPTENIVL	EVAVLSTEGQ	IQDFKFPLGI	KGAGSSIQLS
ANTVKQNSRN	GLAKLVFIIY	RSLGQFLSTE	NATIKLGADF	IGRNSTIAVN
SHVISVSINK	ESSRVYLTDP	VLFTLPHIDP	DNYFNANCSF	WNYSERTMMG
YWSTQGCKLV	DTNKTRTTCA	CSHLTNFAIL	MAHREIAYKD	GVHELLLTVI
TWVGIVISLV	CLAICIFTFC	FFRGLQSDRN	TIHKNLCINL	FIAEFIFLIG
IDKTKYAIAC	PIFAGLLHFF	FLAAFAWMCL	EGVQLYLMLV	EVFESEYSRK
KYYYVAGYLF	PATVVGVSAA	IDYKSYGTEK	ACWLHVDNYF	IWSFIGPVTF
IILLNIIFLV	ITLCKMVKHS	NTLKPDSSRL	ENIKSWVLGA	FALLCLLGLT
WSFGLLFINE	ETIVMAYLFT	IFNAFQGVFI	FIFHCALQKK	VRKEYGKCFR
HSYCCGGLPT	ESPHSSVKAS	TTRTSARYSS	GTQSRIRRMW	NDTVRKQSES
SFISGDINST	STLNQGMTGN	YLLTNPLLRP	HGTNNPYNTL	LAETVVCNAP
SAPVFNSPGH	SLNNARDTSA	MDTLPLNGNF	NNSYSLHKGD	YNDSVQVVDC
GLSLNDTAFE	KMIISELVHN	NLRGSSKTHN	LELTLPVKPV	IGGSSSEDDA
IVADASSLMH	SDNPGLELHH	KELEAPLIPQ	RTHSLLYQPQ	KKVKSEGTDS
YVSQLTAEAE	DHLQSPNRDS	LYTSMPNLRD	SPYPESSPDM	EEDLSPSRRS
ENEDIYYKSM	PNLGAGHQLQ	MCYQISRGNS	DGYIIPINKE	GCIPEGDVRE
GQMQLVTSL

Funkcija

Ovaj gen kodira člana potporodice latrofilinskih receptora vezanih za G-protein (GPCR). Latrofilini mogu funkcionirati i u ćelijskoj adheziji i u prijenosu signala. U eksperimentima s neljudskim vrstama, endogeno proteolitsko cijepanje unutar cisteinom bogatog GPS domena (mjesto proteolize G-protein spregnutog receptora) rezultiralo je u dvije podjedinice (velika vanćelijska N-terminal podjedinica ćelijske adhezije i podjedinica sa značajnom sličnošću sa porodica sekretin/kalcitonin GPCR-a) koji su nekovalentno vezani na ćelijskoj membrani. Iako je opisano nekoliko varijanti transkripta, utvrđena je biološka valjanost samo jedne.^[6]

Također pogledajte

Adhezijski G-proteini spregnuti receptori

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
^ ^a ^b ^c "Entrez Gene: LPHN2 latrophilin 2".

Dopunska literatura

Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi:10.1038/sj.onc.1202487. PMID 10030676.
Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi:10.1074/jbc.C000490200. PMID 10964907.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007. PMID 17456239.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10760572-5] White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.

[entrez-6] "Entrez Gene: LPHN2 latrophilin 2".

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