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Comparative Study
. 2006 Mar;70(3):222-6.
doi: 10.1253/circj.70.222.

Differences between men and women in terms of clinical features of ST-segment elevation acute myocardial infarction

Masami Kosuge  1 , Kazuo Kimura, Toshiyuki Ishikawa, Toshiaki Ebina, Kiyoshi Hibi, Kengo Tsukahara, Masahiko Kanna, Noriaki Iwahashi, Jyun Okuda, Naoki Nozawa, Hiroyuki Ozaki, Hideto Yano, Tatsuya Nakati, Ikuyoshi Kusama, Satoshi Umemura
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Free article
Comparative Study

Differences between men and women in terms of clinical features of ST-segment elevation acute myocardial infarction

Masami Kosuge et al. Circ J. 2006 Mar.
Free article

Abstract

Background: Many studies have examined sex-related differences in the clinical features of acute myocardial infarction (AMI). However, prospective studies are scant, and sex-related differences in symptoms of AMI remain unclear. We examined differences between men and women in terms of the clinical features of ST-segment elevation AMI.

Methods and results: We studied 457 patients (106 women and 351 men) with ST-segment elevation AMI who were admitted within 24 h after symptom onset. The same cardiologist interviewed all patients within 48 h after admission. Women were older than men (72 vs 62 years, p<0.001) and had higher rates of hypertension (70 vs 56%, p=0.010), diabetes mellitus (36 vs 26%, p=0.047), and hyperlipidemia (51 vs 38%, p=0.019). Women were more likely than men to have non-specific symptoms (45 vs 34%, p=0.033), non-chest pain (pain in the jaw, throat, neck, shoulder, arm, hand, and back), mild pain (20 vs 7%, p<0.001), and nausea (49 vs 36%, p=0.013). On coronary angiography, the severity of coronary-artery lesions was similar in both sexes. In-hospital mortality was significantly higher in women than in men (6.6 vs 1.4%, p=0.003).

Conclusions: Clinical profiles and presentations differ between women and men with AMI. Women have less typical symptoms of AMI than men.

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