Entry |
|
Name |
Capmatinib (USAN/INN) |
Formula |
C23H17FN6O
|
Exact mass |
412.1448
|
Mol weight |
412.42
|
Structure |

|
Simcomp |
|
Class |
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02953 AOX1 substrate
|
Remark |
Product (DG02081): | D10891<JP/US> |
|
Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
Target |
|
Pathway |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576], AOX1 [HSA: 316]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EX Other protein kinase inhibitors
L01EX17 Capmatinib
D10696 Capmatinib (USAN/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG02081 Capmatinib
D10696 Capmatinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02081 Capmatinib
D10696 Capmatinib
DG02953 AOX1 substrate
DG02081 Capmatinib
D10696 Capmatinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
MET family
MET
D10696 Capmatinib (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10696
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG02081 Capmatinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02081 Capmatinib
DG02953 AOX1 substrate
DG02081 Capmatinib
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 31
1 C8y C 15.2600 -35.4900
2 C8y C 15.2600 -36.8900
3 C8x C 16.4724 -37.5900
4 C8x C 17.6849 -36.8900
5 C8y C 17.6849 -35.4900
6 C8x C 16.4724 -34.7900
7 C8y C 18.9160 -34.7790
8 X F 14.0476 -34.7900
9 C5a C 14.0476 -37.5900
10 N1b N 12.8521 -36.8996
11 O5a O 14.0475 -38.9898
12 C1a C 11.6647 -37.5851
13 N5x N 20.1212 -35.4747
14 N4y N 21.3335 -34.7746
15 C8y C 21.3335 -33.3746
16 N5x N 20.1283 -32.6789
17 C8x C 18.9159 -33.3790
18 C8y C 22.6651 -35.2071
19 C8x C 23.4879 -34.0745
20 N5x N 22.6649 -32.9419
21 C1b C 23.1000 -36.5455
22 C8y C 24.4683 -36.5563
23 C8x C 25.1591 -37.7751
24 C8y C 26.5591 -37.7862
25 C8y C 27.2687 -36.5794
26 C8x C 26.5778 -35.3606
27 C8x C 25.1779 -35.3495
28 C8x C 27.2494 -39.0042
29 C8x C 28.6494 -39.0153
30 C8x C 29.3590 -37.8084
31 N5x N 28.6686 -36.5905
BOND 35
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 1 8 1
9 2 9 1
10 9 10 1
11 9 11 2
12 10 12 1
13 7 13 2
14 13 14 1
15 14 15 1
16 15 16 1
17 16 17 2
18 7 17 1
19 14 18 1
20 18 19 2
21 19 20 1
22 15 20 2
23 18 21 1
24 21 22 1
25 22 23 2
26 23 24 1
27 24 25 2
28 25 26 1
29 26 27 2
30 22 27 1
31 24 28 1
32 28 29 2
33 29 30 1
34 30 31 2
35 25 31 1
|