When Anne catches her fiancé with someone else the day before her wedding, she moves back in with her parents and accepts a job as a physician assistant at the hospital where her father works as a prominent doctor. But her childhood crush Mark Meijer works there too..
Despite the fact that Anne broke off her engagement, she doesn't want to go to her parents' 34th wedding anniversary alone. She has her sights set on Mark, but her mother has someone else in mind for her daughter.
Anne joins a medical test panel for a new diet pill, but finds out that the doctor examining this new drug is fraudulent. Meanwhile, Ellen finds evidence that Frans is cheating on her.
Anne doesn't know whether to choose for a steamy affair with Mark or an adult love affair with Sam. Natascha does not like competition and takes countermeasures.
Anne finds out that Sam is selflessly providing medical care in a deprived neighborhood. Natascha lures Mark into a trap and Ellen and Anne find out that Frans's mistress is no stranger.
Anne only tries to be friends with Sam because he is married, his wife is in a coma and he has a daughter. The friend thing turns out to be easier said than done.
Now that Sam and Anne have finally found each other, she notices that she is getting a free promotional gift: his daughter Lisa. Mark is trying to get rid of his unborn child by convincing Natascha of an abortion.
Anne's love happiness staggers again when Sam's wife comes out of her coma after fourteen months and he chooses his family. Eline finds out that the role of mistress suits her better than the role of the loving woman.
