FMO4

FMO4
Identifikatori
Alijasi	FMO4
Spoljašnji ID	OMIM: 136131 MGI: 2429497 HomoloGene: 68219 GeneCards: FMO4
Genska lokacija (miš)
Hr.	Chromosome 1 (mouse)
Kraj	162,641,541 bp
Obrazac RNK izražavanja
	More reference expression data
Ortolozi
	2329
	226564
	ENSG00000076258
	ENSMUSG00000026692
	P31512
	Q8VHG0
	NM_002022
	NM_144878
	NP_002013
	NP_659127
	Wikidata
View/Edit Human	View/Edit Mouse

Dimetilanilin monooksigenaza (N-oksid-formirajuća) 4 je enzim koji je kod ljudi kodiran FMO4 genom.^[4]^[5]

Funkcija

Metabolička N-oksidacija amino-trimetilamina (TMA) iz hrane je posredovana monooksigenazom koja sadrži flavin. Ovaj gen ispoljava nasledni FMO3 polimorfizam kod ljudi koji rezultira u maloj potpopulaciji sa umanjenom TMA N-oksidacionom sposobnošću, posledica čega je sindrom zadaha ribe, trimetilaminurija. Tri forme ovog enzima, FMO1 u fetalnoj jetri, FMO2 u jetri odraslih osoba, i FMO3 su kodirani genima koji su grupisani u 1q23-q25 regionu. Monooksigenze koje sadrže flavin su NADPH zavisni flavoenzimi koji katalizuju oksidaciju nukleofilnih heteroatomskih centera ksenobiotika kao što su pesticidi i lekovi.^[5]

Vidi još

Dimetilanilin monooksigenaza (formiranje N-oksida)

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000026692 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lawton MP, Cashman JR, Cresteil T, Dolphin CT, Elfarra AA, Hines RN, Hodgson E, Kimura T, Ozols J, Phillips IR (1994). „A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities”. Arch Biochem Biophys. 308 (1): 254—7. PMID 8311461. doi:10.1006/abbi.1994.1035.
^ ^а ^б „Entrez Gene: FMO4 flavin containing monooxygenase 4”.

Literatura

Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM (1994). „The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression”. Toxicol. Appl. Pharmacol. 125 (1): 1—6. PMID 8128486. doi:10.1006/taap.1994.1042.
Dolphin CT, Shephard EA, Povey S, Smith RL, Phillips IR (1992). „Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family”. Biochem. J. 287 ( Pt 1) (Pt 1): 261—7. PMC 1133153  . PMID 1417778.
Phillips IR, Dolphin CT, Clair P, Hadley MR, Hutt AJ, McCombie RR, Smith RL, Shephard EA (1995). „The molecular biology of the flavin-containing monooxygenases of man”. Chem. Biol. Interact. 96 (1): 17—32. PMID 7720101. doi:10.1016/0009-2797(94)03580-2.
Itagaki K, Carver GT, Philpot RM (1996). „Expression and characterization of a modified flavin-containing monooxygenase 4 from humans”. J. Biol. Chem. 271 (33): 20102—7. PMID 8702731. doi:10.1074/jbc.271.33.20102.
Janmohamed A, Dolphin CT, Phillips IR, Shephard EA (2001). „Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450”. Biochem. Pharmacol. 62 (6): 777—86. PMID 11551524. doi:10.1016/S0006-2952(01)00718-3.
Furnes B, Feng J, Sommer SS, Schlenk D (2003). „Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans”. Drug Metab. Dispos. 31 (2): 187—93. PMID 12527699. doi:10.1124/dmd.31.2.187.

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000026692 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8311461-4] Lawton MP, Cashman JR, Cresteil T, Dolphin CT, Elfarra AA, Hines RN, Hodgson E, Kimura T, Ozols J, Phillips IR (1994). „A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities”. Arch Biochem Biophys. 308 (1): 254—7. PMID 8311461. doi:10.1006/abbi.1994.1035.

[entrez-5] а ^б „Entrez Gene: FMO4 flavin containing monooxygenase 4”.

[4]