پوزانیکلین

پوزانیکلین
شناسه‌ها
	نام آیوپاک 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine;
شمارهٔ سی‌ای‌اس	161417-03-4 ;
پاب‌کم CID	178052;
کم‌اسپایدر	155000 ;
UNII	CL2002R563;
CompTox Dashboard (EPA)	DTXSID20167149 ;
داده‌های فیزیکی و شیمیایی
فرمول شیمیایی	C11H16N2O
جرم مولی	۱۹۲٫۲۶۲ g·mol−1
مدل سه بعدی (جی‌مول)	Interactive image;
	SMILES CC1=C(C=CC=N1)OC[C@@H]2CCCN2;
	InChI InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1 ; Key:YRVIKLBSVVNSHF-JTQLQIEISA-N ;
	(این چیست؟) (صحت‌سنجی)

پوزانیکلین (انگلیسی: Pozanicline)^[۱] دارویی است دارای اثرات نوتروپیک و محافظت کننده عصبی است.^[۲]^[۳]^[۴] پژوهش‌های جانوری نشان داد که برای درمان ADHD سودمند است.^[۵]

منابع

↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF). World Health Organization. p. 257. Archived (PDF) from the original on 18 May 2016. Retrieved 3 January 2017.
↑ Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. (January 1997). "Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties". Journal of Medicinal Chemistry. 40 (3): 385–90. doi:10.1021/jm960233u. PMID 9022806.
↑ Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 235–46. PMID 9336329.
↑ Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 247–58. PMID 9336330.
↑ Prendergast MA, Jackson WJ, Terry AV, Decker MW, Arneric SP, Buccafusco JJ (March 1998). "Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys". Psychopharmacology. 136 (1): 50–8. doi:10.1007/s002130050538. PMID 9537682. S2CID 20080069.

مشارکت‌کنندگان ویکی‌پدیا. «Pozanicline». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ آوریل ۲۰۲۴.

پیوند به بیرون

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[INN-1] "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF). World Health Organization. p. 257. Archived (PDF) from the original on 18 May 2016. Retrieved 3 January 2017.

[2] Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. (January 1997). "Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties". Journal of Medicinal Chemistry. 40 (3): 385–90. doi:10.1021/jm960233u. PMID 9022806.

[3] Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 235–46. PMID 9336329.

[4] Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. (October 1997). "ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 247–58. PMID 9336330.

[5] Prendergast MA, Jackson WJ, Terry AV, Decker MW, Arneric SP, Buccafusco JJ (March 1998). "Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys". Psychopharmacology. 136 (1): 50–8. doi:10.1007/s002130050538. PMID 9537682. S2CID 20080069.

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