S100A8

S100A8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV
Identifiers
Aliases	S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8, S100-A8
External IDs	OMIM: 123885; MGI: 88244; HomoloGene: 2225; GeneCards: S100A8; OMA:S100A8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,391,073 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,577,342 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; gums; ; body of tongue; ; oral cavity; ; trabecular bone; ; gingival epithelium; ; periodontal fiber; ; monocyte; ; bone marrow; ; vulva;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; gastrula; ; femur; ; body of femur; ; fetal liver hematopoietic progenitor cell; ; decidua; ; human fetus; ; spleen; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Toll-like receptor 4 binding; RAGE receptor binding; microtubule binding; protein binding; calcium ion binding; arachidonic acid binding; zinc ion binding; metal ion binding;
Cellular component	nucleus; cytoskeleton; cytosol; extracellular exosome; membrane; plasma membrane; cytoplasm; extracellular space; secretory granule lumen; intermediate filament cytoskeleton; extracellular region; collagen-containing extracellular matrix;
Biological process	regulation of inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; immune system process; positive regulation of inflammatory response; neutrophil chemotaxis; positive regulation of intrinsic apoptotic signaling pathway; defense response to fungus; response to ethanol; chemokine production; response to zinc ion; acute inflammatory response; defense response to bacterium; leukocyte migration involved in inflammatory response; peptidyl-cysteine S-nitrosylation; sequestering of zinc ion; neutrophil aggregation; response to lipopolysaccharide; chemotaxis; positive regulation of peptide secretion; chronic inflammatory response; astrocyte development; wound healing; apoptotic process; positive regulation of cell growth; autophagy; inflammatory response; regulation of cytoskeleton organization; cytokine production; positive regulation of NF-kappaB transcription factor activity; innate immune response; toll-like receptor signaling pathway; antimicrobial humoral response; neutrophil degranulation; autocrine signaling;
	Sources:Amigo / QuickGO
Orthologs
	6279
	20201
	ENSG00000143546
	ENSMUSG00000056054
	P05109
	P27005
	NM_002964; NM_001319196; NM_001319197; NM_001319198; NM_001319201
	NM_013650
	NP_001306125; NP_001306126; NP_001306127; NP_001306130; NP_002955
	NP_038678
	Wikidata
View/Edit Human	View/Edit Mouse

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S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.^[5] It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis ^[5] and post COVID-19 condition.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143546 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056054 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: S100A8 S100 calcium binding protein A8".
^ Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. (January 2022). "Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection". BMC Medicine. 20 (1): 26. doi:10.1186/s12916-021-02228-6. PMC 8758383. PMID 35027067.

Schäfer BW, Heizmann CW (April 1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends in Biochemical Sciences. 21 (4): 134–140. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470.
Kerkhoff C, Klempt M, Sorg C (December 1998). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1448 (2): 200–211. doi:10.1016/S0167-4889(98)00144-X. PMID 9920411.
Nacken W, Roth J, Sorg C, Kerkhoff C (April 2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity". Microscopy Research and Technique. 60 (6): 569–580. doi:10.1002/jemt.10299. PMID 12645005. S2CID 10145841.
Roth J, Vogl T, Sorg C, Sunderkötter C (April 2003). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends in Immunology. 24 (4): 155–158. doi:10.1016/S1471-4906(03)00062-0. PMID 12697438.
Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
Lemarchand P, Vaglio M, Mauël J, Markert M (September 1992). "Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation". The Journal of Biological Chemistry. 267 (27): 19379–19382. doi:10.1016/S0021-9258(18)41786-3. PMID 1326551.
Schäfer T, Sachse GE, Gassen HG (January 1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells". Biological Chemistry Hoppe-Seyler. 372 (1): 1–4. doi:10.1515/bchm3.1991.372.1.1. PMID 2039599.
Dorin JR, Emslie E, van Heyningen V (November 1990). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3". Genomics. 8 (3): 420–426. doi:10.1016/0888-7543(90)90027-R. PMID 2149559.
Wilkinson MM, Busuttil A, Hayward C, Brock DJ, Dorin JR, Van Heyningen V (October 1988). "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues". Journal of Cell Science. 91 ( Pt 2) (2): 221–230. doi:10.1242/jcs.91.2.221. PMID 3267695.
Odink K, Cerletti N, Brüggen J, Clerc RG, Tarcsay L, Zwadlo G, et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis". Nature. 330 (6143): 80–82. Bibcode:1987Natur.330...80O. doi:10.1038/330080a0. PMID 3313057. S2CID 4366579.
Lagasse E, Clerc RG (June 1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation". Molecular and Cellular Biology. 8 (6): 2402–2410. doi:10.1128/mcb.8.6.2402. PMC 363438. PMID 3405210.
Dorin JR, Novak M, Hill RE, Brock DJ, Secher DS, van Heyningen V (1987). "A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene". Nature. 326 (6113): 614–617. Bibcode:1987Natur.326..614D. doi:10.1038/326614a0. PMID 3561500. S2CID 4242084.
Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (February 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–643. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Umekawa T, Kurita T (September 1994). "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone". Biochemistry and Molecular Biology International. 34 (2): 309–313. PMID 7849642.
Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW (July 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proceedings of the National Academy of Sciences of the United States of America. 90 (14): 6547–6551. Bibcode:1993PNAS...90.6547E. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
Roth J, Burwinkel F, van den Bos C, Goebeler M, Vollmer E, Sorg C (September 1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner". Blood. 82 (6): 1875–1883. doi:10.1182/blood.V82.6.1875.1875. PMID 8400238.
Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (February 1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena". Journal of Dental Research. 72 (2): 517–523. doi:10.1177/00220345930720020801. PMID 8423249. S2CID 8311930.
Marti T, Erttmann KD, Gallin MY (April 1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochemical and Biophysical Research Communications. 221 (2): 454–458. doi:10.1006/bbrc.1996.0616. PMID 8619876.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143546 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056054 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S100A8 S100 calcium binding protein A8".

[6] Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. (January 2022). "Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection". BMC Medicine. 20 (1): 26. doi:10.1186/s12916-021-02228-6. PMC 8758383. PMID 35027067.

[1]

References

Further reading