MTMR9

MTMR9
Identifiers
Aliases	MTMR9, C8orf9, LIP-STYX, MTMR8, myotubularin related protein 9
External IDs	OMIM: 606260; MGI: 2442842; HomoloGene: 9148; GeneCards: MTMR9; OMA:MTMR9 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	11,328,146 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	63,781,431 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 46; ; pars compacta; ; Region I of hippocampus proper; ; cerebellar vermis; ; pons; ; secondary oocyte; ; pars reticulata; ; Brodmann area 23; ; middle temporal gyrus;
	Top expressed in
	seminiferous tubule; ; vestibular membrane of cochlear duct; ; ganglionic eminence; ; superior cervical ganglion; ; superior frontal gyrus; ; barrel cortex; ; dentate gyrus of hippocampal formation granule cell; ; ciliary body; ; retinal pigment epithelium; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; enzyme regulator activity; phosphatidylinositol-3-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; protein phosphatase binding;
Cellular component	cytosol; cytoplasm; protein-containing complex; endoplasmic reticulum; plasma membrane; membrane; ruffle membrane; cell projection; perinuclear region of cytoplasm;
Biological process	phosphatidylinositol biosynthetic process; dephosphorylation; negative regulation of autophagy; positive regulation of phosphatase activity; protein stabilization; regulation of phosphatidylinositol dephosphorylation; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	66036
	210376
	ENSG00000104643; ENSG00000285032
	ENSMUSG00000035078
	Q96QG7
	Q9Z2D0
	NM_015458
	NM_177594
	NP_056273
	NP_808262
	Wikidata
View/Edit Human	View/Edit Mouse

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Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene.^[5]^[6]^[7]^[8]

Function

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.^[8]

Interactions

MTMR9 has been shown to interact with MTMR6.^[7]

References

^ ^a ^b ^c ENSG00000285032 GRCh38: Ensembl release 89: ENSG00000104643, ENSG00000285032 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035078 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics. 75 (1–3): 6–8. doi:10.1006/geno.2001.6591. PMID 11472061.
^ Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
^ ^a ^b Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. Bibcode:2003PNAS..100.9768M. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.
^ ^a ^b "Entrez Gene: MTMR9 myotubularin related protein 9".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wang JC, Radford DM, Holt MS, Helms C, Goate A, Brandt W, Parik M, Phillips NJ, DeSchryver K, Schuh ME, Fair KL, Ritter JH, Marshall P, Donis-Keller H (1999). "Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23". Genomics. 60 (1): 1–11. doi:10.1006/geno.1999.5905. PMID 10458905.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000285032 GRCh38: Ensembl release 89: ENSG00000104643, ENSG00000285032 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035078 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11472061-5] Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics. 75 (1–3): 6–8. doi:10.1006/geno.2001.6591. PMID 11472061.

[pmid11896452-6] Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.

[pmid12890864-7] Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. Bibcode:2003PNAS..100.9768M. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.

[entrez-8] "Entrez Gene: MTMR9 myotubularin related protein 9".

[1]

Function

Interactions

References

Further reading