DADLE

DADLE
Names
	IUPAC name (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
	Other names • [D-Ala2, D-Leu5]-Enkephalin; • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine; • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine; • Tyr-D-Ala-Gly-Phe-D-Leu-OH
Identifiers
CAS Number	63631-40-3 ;
3D model (JSmol)	Interactive image;
ChemSpider	5292936 ;
ECHA InfoCard	100.059.337
PubChem CID	6917707;
UNII	HB4QD9GL6F ;
	InChI InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1 Key: ZHUJMSMQIPIPTF-IBURTVSXSA-N ; InChI=1/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1 Key: ZHUJMSMQIPIPTF-IBURTVSXBS;
	SMILES N[C@H](C(N[C@H](C)C(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2;
Properties
Chemical formula	C29H39N5O7
Molar mass	569.659 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

DADLE ([D-Ala², D-Leu⁵]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ₁ subtype of μ-opioid receptors.

Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.^[1]^[2]

Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.

References

^ "Medical Dictionary Online". Archived from the original on 2007-08-28. Retrieved 2007-11-10.
^ Online Medical Dictionary, enkephalin, leucine-2-alanine

This analgesic-related article is a stub. You can help Wikipedia by expanding it.

[1] "Medical Dictionary Online". Archived from the original on 2007-08-28. Retrieved 2007-11-10.

[2] Online Medical Dictionary, enkephalin, leucine-2-alanine

[1]

See also

References